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    Usp51 ubiquitin specific peptidase 51 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317398, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Usp51provided by RGD
    Official Full Name
    ubiquitin specific peptidase 51provided by RGD
    Primary source
    RGD:1562211
    See related
    EnsemblRapid:ENSRNOG00000021434 AllianceGenome:RGD:1562211
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562211
    Summary
    Predicted to enable chromatin binding activity; deubiquitinase activity; and histone binding activity. Predicted to be involved in DNA repair-dependent chromatin remodeling; regulation of cell cycle process; and regulation of double-strand break repair. Orthologous to human USP51 (ubiquitin specific peptidase 51). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 10.0), Brain (RPKM 4.4) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Usp51 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (21750630..21757163, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (18374940..18381472, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (19268352..19273753)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene forkhead box R2 Neighboring gene MAGE family member H1 Neighboring gene ubiquitin specific peptidase 27, X-linked, pseudogene 1 Neighboring gene DExD-box helicase 21, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response. Wang Z, et al. Genes Dev, 2016 Apr 15. PMID 27083998, Free PMC Article
    2. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. Quesada V, et al. Biochem Biophys Res Commun, 2004 Jan 30. PMID 14715245

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H2A deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair-dependent chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 51
    Names
    ubiquitin specific protease 51
    NP_001101722.1
    XP_006256830.1
    XP_038955725.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108252.1 → NP_001101722.1  ubiquitin carboxyl-terminal hydrolase 51

      See identical proteins and their annotated locations for NP_001101722.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474063
      UniProtKB/TrEMBL
      A6KL64, D3ZUR6
      Conserved Domains (2) summary
      cd02660
      Location:360 → 689
      Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam02148
      Location:232 → 292
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      21750630..21757163 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256768.5 → XP_006256830.1  ubiquitin carboxyl-terminal hydrolase 51 isoform X1

      See identical proteins and their annotated locations for XP_006256830.1

      UniProtKB/TrEMBL
      A6KL64, D3ZUR6
      Conserved Domains (2) summary
      cd02660
      Location:360 → 689
      Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam02148
      Location:232 → 292
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    2. XM_039099797.2 → XP_038955725.1  ubiquitin carboxyl-terminal hydrolase 51 isoform X1

      UniProtKB/TrEMBL
      A6KL64, D3ZUR6
      Related
      ENSRNOP00000106025.1, ENSRNOT00000140639.1
      Conserved Domains (2) summary
      cd02660
      Location:360 → 689
      Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam02148
      Location:232 → 292
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    Nucleotide Protein Strain
    Heading Accession and Version

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