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    Cntnap4 contactin associated protein family member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307865, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cntnap4provided by RGD
    Official Full Name
    contactin associated protein family member 4provided by RGD
    Primary source
    RGD:1306459
    See related
    EnsemblRapid:ENSRNOG00000011231 AllianceGenome:RGD:1306459
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable PDZ domain binding activity. Predicted to be involved in modulation of chemical synaptic transmission; regulation of grooming behavior; and regulation of synapse organization. Predicted to act upstream of or within neural precursor cell proliferation and neuron differentiation. Predicted to be located in dendrite and plasma membrane. Predicted to be active in GABA-ergic synapse and presynaptic membrane. Orthologous to human CNTNAP4 (contactin associated protein family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 113.8) and Kidney (RPKM 16.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cntnap4 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (57477447..57765173)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (40568684..40861879)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (44817727..45118133)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483515 Neighboring gene small nucleolar RNA U13 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC120098519

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission. Karayannis T, et al. Nature, 2014 Jul 10. PMID 24870235, Free PMC Article
    2. Caspr3 and caspr4, two novel members of the caspr family are expressed in the nervous system and interact with PDZ domains. Spiegel I, et al. Mol Cell Neurosci, 2002 Jun. PMID 12093160

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of grooming behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic transmission, dopaminergic ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    contactin-associated protein-like 4
    Names
    contactin associated protein 4
    contactin associated protein-like 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107432.1 → NP_001100902.1  contactin-associated protein-like 4 precursor

      See identical proteins and their annotated locations for NP_001100902.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A6IZC7, F1M3J7
      Related
      ENSRNOP00000061027.4, ENSRNOT00000066057.5
      Conserved Domains (7) summary
      smart00231
      Location:57 → 179
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      smart00282
      Location:210 → 343
      LamG; Laminin G domain
      cd00057
      Location:56 → 178
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00110
      Location:796 → 940
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:555 → 586
      EGF; EGF-like domain
      pfam02210
      Location:400 → 526
      Laminin_G_2; Laminin G domain
      cl00085
      Location:597 → 645
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      57477447..57765173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278059.1 → XP_063134129.1  contactin-associated protein-like 4 isoform X1

    2. XM_039097771.2 → XP_038953699.1  contactin-associated protein-like 4 isoform X2

      Conserved Domains (2) summary
      cd00110
      Location:153 → 297
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam02210
      Location:405 → 535
      Laminin_G_2; Laminin G domain
    Nucleotide Protein Strain
    Heading Accession and Version

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