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    Lyzl6 lysozyme-like 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287751, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lyzl6provided by RGD
    Official Full Name
    lysozyme-like 6provided by RGD
    Primary source
    RGD:1306968
    See related
    EnsemblRapid:ENSRNOG00000003501 AllianceGenome:RGD:1306968
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lyzb; RGD1306968
    Summary
    Predicted to enable lysozyme activity. Predicted to be involved in defense response to bacterium and fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be located in sperm midpiece and sperm plasma membrane. Predicted to be active in acrosomal vesicle and sperm flagellum. Orthologous to human LYZL6 (lysozyme like 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 38.2) See more
    Orthologs
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    Genomic context

    See Lyzl6 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (89044375..89049210, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (88544342..88549177, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (91694547..91701428, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480885 Neighboring gene proline rich protein 2-like 1 Neighboring gene uncharacterized LOC103693460 Neighboring gene reprimo-like Neighboring gene golgi SNAP receptor complex member 2 Neighboring gene mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction, pseudogene 1

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lysozyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    lysozyme-like protein 6
    Names
    lysozyme b
    NP_001129305.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135833.1NP_001129305.2  lysozyme-like protein 6 precursor

      See identical proteins and their annotated locations for NP_001129305.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A077S6M4, A0A9K3Y7P2, D3ZSK1
      Related
      ENSRNOP00000004650.5, ENSRNOT00000004650.6
      Conserved Domains (1) summary
      cd00119
      Location:22143
      LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      89044375..89049210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)