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    Nsl1 NSL1 component of MIS12 kinetochore complex [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498310, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Nsl1provided by RGD
    Official Full Name
    NSL1 component of MIS12 kinetochore complexprovided by RGD
    Primary source
    RGD:1562052
    See related
    AllianceGenome:RGD:1562052
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562052
    Summary
    Predicted to be involved in mitotic sister chromatid segregation. Predicted to be located in kinetochore and nuclear speck. Predicted to be part of MIS12/MIND type complex. Orthologous to human NSL1 (NSL1 component of MIS12 kinetochore complex). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 69.5), Spleen (RPKM 41.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nsl1 in Genome Data Viewer
    Location:
    13q27
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (105176163..105205179)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (102649050..102674059)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (109669646..109697849)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene FLVCR choline and heme transporter 1 Neighboring gene spermatogenesis associated 45 Neighboring gene TatD DNase domain containing 3 Neighboring gene uncharacterized LOC120096350 Neighboring gene basic leucine zipper ATF-like transcription factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. Kline SL, et al. J Cell Biol, 2006 Apr 10. PMID 16585270, Free PMC Article
    2. A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Cheeseman IM, et al. Genes Dev, 2004 Sep 15. PMID 15371340, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mitotic sister chromatid segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of MIS12/MIND type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MIS12/MIND type complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of outer kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kinetochore-associated protein NSL1 homolog
    Names
    NSL1, MIND kinetochore complex component, homolog
    NSL1, MIS12 kinetochore complex component

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109083.1 → NP_001102553.1  kinetochore-associated protein NSL1 homolog

      See identical proteins and their annotated locations for NP_001102553.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473985
      UniProtKB/TrEMBL
      A6JGY4
      Conserved Domains (1) summary
      pfam08641
      Location:82 → 196
      Mis14; Kinetochore protein Mis14 like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      105176163..105205179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272553.1 → XP_063128623.1  kinetochore-associated protein NSL1 homolog isoform X2

    2. XM_006250488.4 → XP_006250550.1  kinetochore-associated protein NSL1 homolog isoform X1

      UniProtKB/TrEMBL
      F1M3N2
      Conserved Domains (1) summary
      pfam08641
      Location:82 → 197
      Mis14; Kinetochore protein Mis14 like
    Nucleotide Protein Strain
    Heading Accession and Version

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