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    Cdc42 cell division cycle 42 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64465, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdc42provided by RGD
    Official Full Name
    cell division cycle 42provided by RGD
    Primary source
    RGD:71043
    See related
    EnsemblRapid:ENSRNOG00000013536 AllianceGenome:RGD:71043
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables GTP binding activity and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including actin filament branching; establishment of Golgi localization; and regulation of synapse organization. Located in Golgi membrane; plasma membrane; and secretory granule. Is active in Schaffer collateral - CA1 synapse. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in fibrosarcoma. Orthologous to human CDC42 (cell division cycle 42). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 651.4), Thymus (RPKM 615.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cdc42 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (154838478..154876629, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (149555069..149593239, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (155690267..155728385, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552931 Neighboring gene Wnt family member 4 Neighboring gene RIKEN cDNA 1700013G24 gene like Neighboring gene chymotrypsin like elastase 3B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein activity  
    enables GBD domain binding  
    enables GTP binding  
    enables GTP binding PubMed 
    enables GTP binding  
    enables GTP binding  
    enables GTP binding PubMed 
    enables GTP-dependent protein binding  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity PubMed 
    enables apolipoprotein A-I receptor binding  
    enables identical protein binding  
    enables membrane scission GTPase motor activity  
    enables mitogen-activated protein kinase kinase kinase binding PubMed 
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein kinase binding  
    enables thioesterase binding  
    enables ubiquitin protein ligase activity  
    Items 1 - 25 of 86
    Process Evidence Code Pubs
    involved_in Cdc42 protein signal transduction  
    involved_in Golgi organization PubMed 
    involved_in actin cytoskeleton organization  
    involved_in actin filament branching PubMed 
    involved_in actin filament organization  
    involved_in actin filament organization PubMed 
    involved_in actin filament organization  
    involved_in actin filament organization  
    acts_upstream_of_or_within adherens junction organization  
    involved_in anatomical structure morphogenesis  
    acts_upstream_of_or_within cardiac conduction system development  
    involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis  
    involved_in cell junction assembly  
    involved_in cell junction assembly  
    acts_upstream_of_or_within cellular response to type II interferon  
    acts_upstream_of_or_within dendritic cell migration  
    involved_in dendritic spine morphogenesis  
    involved_in dendritic spine morphogenesis  
    involved_in embryonic heart tube development  
    involved_in endocytosis  
    acts_upstream_of_or_within endocytosis  
    involved_in endothelin receptor signaling pathway involved in heart process  
    involved_in establishment of Golgi localization PubMed 
    involved_in establishment of cell polarity  
    involved_in establishment of cell polarity PubMed 
    involved_in establishment of epithelial cell apical/basal polarity  
    involved_in establishment of epithelial cell apical/basal polarity  
    acts_upstream_of_or_within establishment of localization in cell  
    acts_upstream_of_or_within establishment or maintenance of apical/basal cell polarity  
    involved_in establishment or maintenance of cell polarity  
    acts_upstream_of_or_within filopodium assembly  
    acts_upstream_of_or_within heart contraction  
    involved_in heart process  
    involved_in integrin-mediated signaling pathway  
    involved_in modulation by host of viral process  
    involved_in negative regulation of protein-containing complex assembly  
    acts_upstream_of_or_within neuron fate determination  
    involved_in neuropilin signaling pathway  
    acts_upstream_of_or_within nuclear migration  
    acts_upstream_of_or_within nucleus localization  
    involved_in organelle transport along microtubule PubMed 
    involved_in phagocytosis, engulfment  
    involved_in phagocytosis, engulfment  
    involved_in positive regulation of DNA replication PubMed 
    involved_in positive regulation of JNK cascade PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade  
    involved_in positive regulation of catalytic activity PubMed 
    involved_in positive regulation of cell growth  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cellular component organization  
    involved_in positive regulation of cytokinesis  
    involved_in positive regulation of cytokinesis  
    involved_in positive regulation of epithelial cell proliferation involved in lung morphogenesis  
    involved_in positive regulation of filopodium assembly  
    involved_in positive regulation of filopodium assembly  
    involved_in positive regulation of intracellular protein transport PubMed 
    involved_in positive regulation of lamellipodium assembly  
    involved_in positive regulation of neuron apoptotic process PubMed 
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of pinocytosis  
    involved_in positive regulation of pinocytosis  
    involved_in positive regulation of pseudopodium assembly  
    involved_in positive regulation of stress fiber assembly  
    involved_in positive regulation of substrate adhesion-dependent cell spreading  
    involved_in positive regulation of substrate adhesion-dependent cell spreading  
    involved_in positive regulation of synapse structural plasticity PubMed 
    acts_upstream_of_or_within protein localization  
    involved_in protein phosphorylation  
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of attachment of spindle microtubules to kinetochore  
    involved_in regulation of attachment of spindle microtubules to kinetochore  
    involved_in regulation of exocytosis PubMed 
    involved_in regulation of filopodium assembly  
    involved_in regulation of filopodium assembly  
    involved_in regulation of filopodium assembly  
    involved_in regulation of lamellipodium assembly  
    acts_upstream_of_or_within regulation of mitotic nuclear division  
    involved_in regulation of modification of postsynaptic structure PubMed 
    involved_in regulation of modification of postsynaptic structure PubMed 
    involved_in regulation of postsynapse organization  
    involved_in regulation of stress fiber assembly  
    involved_in response to glucose PubMed 
    involved_in small GTPase-mediated signal transduction  
    involved_in sprouting angiogenesis PubMed 
    involved_in submandibular salivary gland formation PubMed 
    involved_in substantia nigra development PubMed 
    Items 1 - 25 of 86
    Items 1 - 20 of 40
    Component Evidence Code Pubs
    located_in Golgi membrane PubMed 
    part_of Golgi transport complex  
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    located_in apical part of cell  
    is_active_in cell leading edge  
    located_in cell periphery  
    located_in cell projection  
    located_in cell-cell junction  
    located_in centrosome  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasmic ribonucleoprotein granule  
    located_in cytosol  
    located_in cytosol  
    is_active_in dendritic spine  
    located_in filopodium  
    is_active_in glutamatergic synapse  
    located_in lamellipodium membrane  
    located_in leading edge membrane  
    located_in membrane  
    located_in membrane  
    located_in midbody  
    located_in midbody  
    located_in midbody  
    located_in mitotic spindle  
    located_in mitotic spindle  
    located_in neuron projection  
    located_in neuronal cell body  
    located_in phagocytic vesicle  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynapse  
    part_of protein-containing complex  
    located_in secretory granule PubMed 
    located_in spindle midzone  
    located_in spindle midzone  
    located_in storage vacuole  
    Items 1 - 20 of 40

    General protein information

    Preferred Names
    cell division control protein 42 homolog
    Names
    cell division cycle 42 (GTP binding protein)
    cell division cycle 42 homolog
    NP_741991.3
    XP_008762508.1
    XP_008762509.1
    XP_038966637.1
    XP_063144422.1
    XP_063144423.1
    XP_063144424.1
    XP_063144425.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_171994.5NP_741991.3  cell division control protein 42 homolog

      See identical proteins and their annotated locations for NP_741991.3

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q6P9Y3, Q71TW5, Q8CFN2
      UniProtKB/TrEMBL
      A6ITD3
      Related
      ENSRNOP00000030928.2, ENSRNOT00000029025.7
      Conserved Domains (1) summary
      cd01874
      Location:3177
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      154838478..154876629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764287.4XP_008762509.1  cell division control protein 42 homolog isoform X2

      See identical proteins and their annotated locations for XP_008762509.1

      UniProtKB/TrEMBL
      A0A0G2JSM8, A6ITD4
      Related
      ENSRNOP00000018118.2, ENSRNOT00000018118.7
      Conserved Domains (1) summary
      cd01874
      Location:3177
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
    2. XM_063288354.1XP_063144424.1  cell division control protein 42 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q6P9Y3, Q71TW5, Q8CFN2
      UniProtKB/TrEMBL
      A6ITD3
    3. XM_063288355.1XP_063144425.1  cell division control protein 42 homolog isoform X2

      UniProtKB/TrEMBL
      A0A0G2JSM8, A6ITD4
    4. XM_063288352.1XP_063144422.1  cell division control protein 42 homolog isoform X2

      UniProtKB/TrEMBL
      A0A0G2JSM8, A6ITD4
    5. XM_008764286.4XP_008762508.1  cell division control protein 42 homolog isoform X1

      See identical proteins and their annotated locations for XP_008762508.1

      UniProtKB/Swiss-Prot
      Q6P9Y3, Q71TW5, Q8CFN2
      UniProtKB/TrEMBL
      A6ITD3
      Conserved Domains (1) summary
      cd01874
      Location:3177
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
    6. XM_039110709.2XP_038966637.1  cell division control protein 42 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q6P9Y3, Q71TW5, Q8CFN2
      UniProtKB/TrEMBL
      A6ITD3
      Conserved Domains (1) summary
      cd01874
      Location:3177
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
    7. XM_063288353.1XP_063144423.1  cell division control protein 42 homolog isoform X2

      UniProtKB/TrEMBL
      A0A0G2JSM8, A6ITD4
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