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    Mark3 microtubule affinity regulating kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170577, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mark3provided by RGD
    Official Full Name
    microtubule affinity regulating kinase 3provided by RGD
    Primary source
    RGD:619883
    See related
    EnsemblRapid:ENSRNOG00000010330 AllianceGenome:RGD:619883
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in several processes, including negative regulation of hippo signaling; negative regulation of protein localization to nucleus; and peptidyl-serine autophosphorylation. Predicted to be located in dendrite. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to human MARK3 (microtubule affinity regulating kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 238.7), Brain (RPKM 224.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mark3 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (136447327..136537409)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (130626612..130716245)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (136040957..136129780)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103627 Neighboring gene small nucleolar RNA, H/ACA box 28 Neighboring gene eukaryotic translation initiation factor 5 Neighboring gene carnitine palmitoyltransferase 1A like 1 Neighboring gene tRNA methyltransferase 61A Neighboring gene creatine kinase B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids. Moravcevic K, et al. Cell, 2010 Dec 10. PMID 21145462, Free PMC Article
    2. New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. Dequiedt F, et al. Mol Cell Biol, 2006 Oct. PMID 16980613, Free PMC Article
    3. C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. Peng CY, et al. Cell Growth Differ, 1998 Mar. PMID 9543386
    4. Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease. Gu GJ, et al. Neuromolecular Med, 2013 Sep. PMID 23666762
    5. DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2. Kwan J, et al. Genes Dev, 2016 Dec 15. PMID 28087714, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tau-protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tau-protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tau-protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tau-protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of hippo signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of hippo signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-serine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    MAP/microtubule affinity-regulating kinase 3
    NP_570105.1
    XP_006240625.1
    XP_017449499.2
    XP_017449500.2
    XP_038967643.1
    XP_038967645.1
    XP_038967646.1
    XP_038967648.1
    XP_038967649.1
    XP_038967651.1
    XP_038967652.1
    XP_038967653.1
    XP_063117565.1
    XP_063117566.1
    XP_063117567.1
    XP_063117568.1
    XP_063117569.1
    XP_063117570.1
    XP_063117571.1
    XP_063117572.1
    XP_063117573.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130749.1 → NP_570105.1  MAP/microtubule affinity-regulating kinase 3

      See identical proteins and their annotated locations for NP_570105.1

      Status: PROVISIONAL

      Source sequence(s)
      AF465412
      UniProtKB/Swiss-Prot
      Q8VHF0
      UniProtKB/TrEMBL
      A0A0G2K554
      Related
      ENSRNOP00000073297.1, ENSRNOT00000088784.4
      Conserved Domains (4) summary
      cd12196
      Location:698 → 795
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:56 → 307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:325 → 367
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:55 → 307
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      136447327..136537409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111723.2 → XP_038967651.1  MAP/microtubule affinity-regulating kinase 3 isoform X18

      Conserved Domains (2) summary
      cd14407
      Location:406 → 448
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:136 → 388
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    2. XM_063261495.1 → XP_063117565.1  MAP/microtubule affinity-regulating kinase 3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JU56

    3. XM_063261496.1 → XP_063117566.1  MAP/microtubule affinity-regulating kinase 3 isoform X8

      UniProtKB/TrEMBL
      A0A0G2JU56

    4. XM_006240563.5 → XP_006240625.1  MAP/microtubule affinity-regulating kinase 3 isoform X6

      See identical proteins and their annotated locations for XP_006240625.1

      UniProtKB/TrEMBL
      A0A0G2K554
      Conserved Domains (4) summary
      cd12196
      Location:707 → 804
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:56 → 307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:325 → 367
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:55 → 307
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    5. XM_063261497.1 → XP_063117567.1  MAP/microtubule affinity-regulating kinase 3 isoform X10

      UniProtKB/TrEMBL
      A0A0G2JU56

    6. XM_063261498.1 → XP_063117568.1  MAP/microtubule affinity-regulating kinase 3 isoform X11

      UniProtKB/TrEMBL
      A0A0G2JU56

    7. XM_063261500.1 → XP_063117570.1  MAP/microtubule affinity-regulating kinase 3 isoform X14

      UniProtKB/TrEMBL
      A0A0G2JU56, A0A8I6GIW6
      Related
      ENSRNOP00000068972.3, ENSRNOT00000080304.3

    8. XM_039111721.2 → XP_038967649.1  MAP/microtubule affinity-regulating kinase 3 isoform X12

      UniProtKB/TrEMBL
      A0A0G2K554
      Conserved Domains (3) summary
      cd12196
      Location:643 → 740
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14407
      Location:261 → 303
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:18 → 243
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    9. XM_063261502.1 → XP_063117572.1  MAP/microtubule affinity-regulating kinase 3 isoform X16

      UniProtKB/TrEMBL
      A0A0G2JU56

    10. XM_063261503.1 → XP_063117573.1  MAP/microtubule affinity-regulating kinase 3 isoform X17

      UniProtKB/TrEMBL
      A0A0G2JU56

    11. XM_063261501.1 → XP_063117571.1  MAP/microtubule affinity-regulating kinase 3 isoform X15

      UniProtKB/TrEMBL
      A0A0G2K554

    12. XM_039111718.2 → XP_038967646.1  MAP/microtubule affinity-regulating kinase 3 isoform X7

      UniProtKB/TrEMBL
      A0A0G2K554, F1M836
      Related
      ENSRNOP00000014395.4, ENSRNOT00000014395.6
      Conserved Domains (3) summary
      cd12196
      Location:699 → 796
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14407
      Location:317 → 359
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:47 → 299
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    13. XM_063261499.1 → XP_063117569.1  MAP/microtubule affinity-regulating kinase 3 isoform X13

      UniProtKB/TrEMBL
      A0A0G2JU56

    14. XM_017594011.3 → XP_017449500.2  MAP/microtubule affinity-regulating kinase 3 isoform X2

      UniProtKB/TrEMBL
      A6KBR9
      Conserved Domains (3) summary
      cd12196
      Location:577 → 674
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14407
      Location:219 → 261
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cl21453
      Location:1 → 201
      PKc_like; Protein Kinases, catalytic domain

    15. XM_017594010.3 → XP_017449499.2  MAP/microtubule affinity-regulating kinase 3 isoform X1

      UniProtKB/TrEMBL
      A6KBR9
      Conserved Domains (3) summary
      cd12196
      Location:585 → 682
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14407
      Location:219 → 261
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cl21453
      Location:1 → 201
      PKc_like; Protein Kinases, catalytic domain

    16. XM_039111715.1 → XP_038967643.1  MAP/microtubule affinity-regulating kinase 3 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JU56
      Conserved Domains (3) summary
      cd12196
      Location:532 → 629
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14407
      Location:219 → 261
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cl21453
      Location:1 → 201
      PKc_like; Protein Kinases, catalytic domain

    17. XM_039111717.1 → XP_038967645.1  MAP/microtubule affinity-regulating kinase 3 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JU56
      Conserved Domains (3) summary
      cd12196
      Location:523 → 620
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14407
      Location:219 → 261
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cl21453
      Location:1 → 201
      PKc_like; Protein Kinases, catalytic domain

    18. XM_039111720.1 → XP_038967648.1  MAP/microtubule affinity-regulating kinase 3 isoform X9

      Conserved Domains (4) summary
      cd12196
      Location:469 → 566
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      PHA03307
      Location:239 → 419
      PHA03307; transcriptional regulator ICP4; Provisional
      cd14407
      Location:140 → 182
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cl21453
      Location:1 → 122
      PKc_like; Protein Kinases, catalytic domain

    19. XM_039111724.2 → XP_038967652.1  MAP/microtubule affinity-regulating kinase 3 isoform X19

      Conserved Domains (1) summary
      cd12196
      Location:359 → 456
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3

    20. XM_039111725.2 → XP_038967653.1  MAP/microtubule affinity-regulating kinase 3 isoform X20

      Conserved Domains (1) summary
      cd12196
      Location:343 → 440
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VHF0.1 GenPept UniProtKB/Swiss-Prot:Q8VHF0

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