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    Ubac2 UBA domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361094, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ubac2provided by RGD
    Official Full Name
    UBA domain containing 2provided by RGD
    Primary source
    RGD:1311689
    See related
    EnsemblRapid:ENSRNOG00000012710 AllianceGenome:RGD:1311689
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Phgdhl1
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and negative regulation of retrograde protein transport, ER to cytosol. Predicted to act upstream of or within protein localization to endoplasmic reticulum. Predicted to be located in endoplasmic reticulum. Orthologous to human UBAC2 (UBA domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 162.5), Heart (RPKM 161.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ubac2 in Genome Data Viewer
    Location:
    15q25
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (105366776..105514435)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (98960139..99107795)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (108286407..108433531)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097092 Neighboring gene uncharacterized LOC134482163 Neighboring gene dedicator of cytokinesis 9 Neighboring gene G protein-coupled receptor 18 Neighboring gene G protein-coupled receptor 183 Neighboring gene uncharacterized LOC108352982 Neighboring gene translocase of inner mitochondrial membrane 8A2 Neighboring gene uncharacterized LOC134482164 Neighboring gene transmembrane 9 superfamily member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover. Olzmann JA, et al. Proc Natl Acad Sci U S A, 2013 Jan 22. PMID 23297223, Free PMC Article
    2. Identification of ERAD components essential for dislocation of the null Hong Kong variant of α-1-antitrypsin (NHK). Zhong Y, et al. Biochem Biophys Res Commun, 2015 Mar 6. PMID 25660456
    3. LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. Choi JH, et al. Science, 2019 May 10. PMID 31073040, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125241

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-associated domain-containing protein 2
    Names
    phosphoglycerate dehydrogenase like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034937.2 → NP_001030109.2  ubiquitin-associated domain-containing protein 2

      See identical proteins and their annotated locations for NP_001030109.2

      Status: VALIDATED

      Source sequence(s)
      BC105842, CB708329, FM053767
      UniProtKB/TrEMBL
      A6HUK7, F1LQF5, F7FKE7
      Related
      ENSRNOP00000016986.5, ENSRNOT00000016986.10
      Conserved Domains (1) summary
      cd14305
      Location:306 → 343
      UBA_UBAC2; UBA domain found in ubiquitin-associated domain-containing protein 2 (UBAC2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      105366776..105514435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252509.5 → XP_006252571.1  ubiquitin-associated domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AW27, F7FKE7
      Related
      ENSRNOP00000092763.1, ENSRNOT00000096210.2
      Conserved Domains (1) summary
      cd14305
      Location:290 → 327
      UBA_UBAC2; UBA domain found in ubiquitin-associated domain-containing protein 2 (UBAC2) and similar proteins

    2. XM_039093541.2 → XP_038949469.1  ubiquitin-associated domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      Q3KR85
      Conserved Domains (1) summary
      cd14305
      Location:123 → 160
      UBA_UBAC2; UBA domain found in ubiquitin-associated domain-containing protein 2 (UBAC2) and similar proteins

    3. XM_063274473.1 → XP_063130543.1  ubiquitin-associated domain-containing protein 2 isoform X2

    4. XM_063274474.1 → XP_063130544.1  ubiquitin-associated domain-containing protein 2 isoform X3

    5. XM_063274475.1 → XP_063130545.1  ubiquitin-associated domain-containing protein 2 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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