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    Ppox protoporphyrinogen oxidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289219, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppoxprovided by RGD
    Official Full Name
    protoporphyrinogen oxidaseprovided by RGD
    Primary source
    RGD:1310543
    See related
    EnsemblRapid:ENSRNOG00000003567 AllianceGenome:RGD:1310543
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables oxygen-dependent protoporphyrinogen oxidase activity. Involved in heme biosynthetic process; protoporphyrinogen IX metabolic process; and response to xenobiotic stimulus. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in variegate porphyria. Orthologous to human PPOX (protoporphyrinogen oxidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 112.8), Liver (RPKM 73.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppox in Genome Data Viewer
    Location:
    13q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (86230111..86235028, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (83697661..83701998, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (89650094..89654998, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 4 Neighboring gene beta-1,4-galactosyltransferase 3 Neighboring gene ubiquitin specific peptidase 21 Neighboring gene ubiquitin-fold modifier conjugating enzyme 1 Neighboring gene G protein subunit gamma 5, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An h.p.l.c. assay for protoporphyrinogen oxidase activity in rat liver. Li F, et al. Biochem J, 1987 May 1. PMID 3663105, Free PMC Article
    2. Rat liver protoporphyrinogen IX oxidase: site of synthesis and factor influencing its activity. Kolarov J, et al. Biochem Biophys Res Commun, 1983 Oct 31. PMID 6316951
    3. Variegate porphyria in South Africa, 1688-1996--new developments in an old disease. Hift RJ, et al. S Afr Med J, 1997 Jun. PMID 9254745
    4. Herbicide-induced experimental variegate porphyria in mice: tissue porphyrinogen accumulation and response to porphyrogenic drugs. Krijt J, et al. Can J Physiol Pharmacol, 1997 Oct-Nov. PMID 9431441
    5. Organization of the terminal two enzymes of the heme biosynthetic pathway. Orientation of protoporphyrinogen oxidase and evidence for a membrane complex. Ferreira GC, et al. J Biol Chem, 1988 Mar 15. PMID 3346226

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables menaquinone-dependent protoporphyrinogen oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen-dependent protoporphyrinogen oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxygen-dependent protoporphyrinogen oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxygen-dependent protoporphyrinogen oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables primary methylamine oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme A biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heme B biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heme O biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heme biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within heme biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heme biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in porphyrin-containing compound biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in porphyrin-containing compound biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protoporphyrinogen IX biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protoporphyrinogen IX metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protoporphyrinogen oxidase
    NP_001099438.1
    XP_006250302.1
    XP_006250303.1
    XP_006250305.1
    XP_038946434.1
    XP_038946436.1
    XP_038946437.1
    XP_063128198.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105968.1 → NP_001099438.1  protoporphyrinogen oxidase

      See identical proteins and their annotated locations for NP_001099438.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473985
      UniProtKB/TrEMBL
      A6JFW5
      Conserved Domains (1) summary
      TIGR00562
      Location:3 → 471
      proto_IX_ox; protoporphyrinogen oxidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      86230111..86235028 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090506.2 → XP_038946434.1  protoporphyrinogen oxidase isoform X2

      UniProtKB/TrEMBL
      A6JFW5
      Conserved Domains (1) summary
      TIGR00562
      Location:3 → 471
      proto_IX_ox; protoporphyrinogen oxidase

    2. XM_006250240.5 → XP_006250302.1  protoporphyrinogen oxidase isoform X1

      See identical proteins and their annotated locations for XP_006250302.1

      UniProtKB/TrEMBL
      D3ZVN7
      Conserved Domains (3) summary
      TIGR00562
      Location:3 → 482
      proto_IX_ox; protoporphyrinogen oxidase
      pfam13450
      Location:7 → 65
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:238 → 372
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. XM_006250241.4 → XP_006250303.1  protoporphyrinogen oxidase isoform X1

      See identical proteins and their annotated locations for XP_006250303.1

      UniProtKB/TrEMBL
      D3ZVN7
      Related
      ENSRNOP00000004896.5, ENSRNOT00000004896.8
      Conserved Domains (3) summary
      TIGR00562
      Location:3 → 482
      proto_IX_ox; protoporphyrinogen oxidase
      pfam13450
      Location:7 → 65
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:238 → 372
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. XM_006250243.3 → XP_006250305.1  protoporphyrinogen oxidase isoform X3

      Conserved Domains (2) summary
      TIGR00562
      Location:18 → 427
      proto_IX_ox; protoporphyrinogen oxidase
      cl21454
      Location:183 → 317
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    5. XM_039090508.2 → XP_038946436.1  protoporphyrinogen oxidase isoform X4

      Conserved Domains (1) summary
      TIGR00562
      Location:45 → 350
      proto_IX_ox; protoporphyrinogen oxidase

    6. XM_063272128.1 → XP_063128198.1  protoporphyrinogen oxidase isoform X4

    7. XM_039090509.2 → XP_038946437.1  protoporphyrinogen oxidase isoform X5

      Conserved Domains (1) summary
      COG1232
      Location:5 → 299
      HemY; Protoporphyrinogen oxidase [Coenzyme transport and metabolism]
    Nucleotide Protein Strain
    Heading Accession and Version

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