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    Zfp451 zinc finger protein 451 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316312, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp451provided by RGD
    Official Full Name
    zinc finger protein 451provided by RGD
    Primary source
    RGD:1305865
    See related
    EnsemblRapid:ENSRNOG00000012718 AllianceGenome:RGD:1305865
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including SUMO ligase activity; transcription corepressor activity; and transcription regulator inhibitor activity. Predicted to be involved in negative regulation of transcription initiation by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; and protein sumoylation. Predicted to be located in PML body. Predicted to be active in nucleus. Orthologous to human ZNF451 (zinc finger protein 451). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 96.4), Testes (RPKM 95.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp451 in Genome Data Viewer
    Location:
    9q21
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (43481395..43546103, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (35985441..36040991, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (38395464..38451585)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2I, pseudogene 5 Neighboring gene BAG cochaperone 2 Neighboring gene ribosomal protein S18, pseudogene 7 Neighboring gene BEN domain containing 6 Neighboring gene dystonin Neighboring gene uncharacterized LOC102551615

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase. Cappadocia L, et al. Nat Struct Mol Biol, 2015 Dec. PMID 26524494, Free PMC Article
    2. Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-β signaling. Feng Y, et al. J Biol Chem, 2014 Jan 24. PMID 24324267, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124741

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription regulator inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription initiation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 SUMO-protein ligase ZNF451

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033705.2 → NP_001028877.2  E3 SUMO-protein ligase ZNF451

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6IN95, G3V7N7, Q3T1G8
      Conserved Domains (2) summary
      pfam05605
      Location:630 → 685
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding
      pfam18479
      Location:876 → 993
      PIN_11; PIN like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      43481395..43546103 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267130.1 → XP_063123200.1  E3 SUMO-protein ligase ZNF451 isoform X1

    2. XM_063267131.1 → XP_063123201.1  E3 SUMO-protein ligase ZNF451 isoform X2

      UniProtKB/TrEMBL
      A6IN94

    3. XM_039083551.2 → XP_038939479.1  E3 SUMO-protein ligase ZNF451 isoform X2

      UniProtKB/TrEMBL
      A6IN94
      Conserved Domains (1) summary
      pfam18479
      Location:737 → 854
      PIN_11; PIN like domain

    4. XM_039083552.2 → XP_038939480.1  E3 SUMO-protein ligase ZNF451 isoform X2

      UniProtKB/TrEMBL
      A6IN94
      Related
      ENSRNOP00000017022.6, ENSRNOT00000017022.9
      Conserved Domains (1) summary
      pfam18479
      Location:737 → 854
      PIN_11; PIN like domain

    RNA

    1. XR_005488896.2 RNA Sequence

    2. XR_005488897.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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