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    Bicd2 BICD cargo adaptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306809, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bicd2provided by RGD
    Official Full Name
    BICD cargo adaptor 2provided by RGD
    Primary source
    RGD:735093
    See related
    EnsemblRapid:ENSRNOG00000016031 AllianceGenome:RGD:735093
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    This gene encodes a dynein-dynactin adaptor protein. In mouse, the protein primarily localizes to the Golgi complex as well as to microtubule plus ends through dynactin. Overexpression studies suggest that the N-terminus mediates the dynein-dynactin interaction, while the C-terminus is responsible for Golgi targeting. Knockout of this gene in mouse results in a defect in cerebellar granule cell migration. In human, mutations in this gene are associated with spinal muscular dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
    Expression
    Biased expression in Heart (RPKM 263.4), Lung (RPKM 200.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bicd2 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (15449011..15511423, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (15259773..15304889, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (15673649..15718035, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene centromere protein P Neighboring gene uncharacterized LOC134482692 Neighboring gene inositol-pentakisphosphate 2-kinase Neighboring gene ribosomal protein S12 like 8 Neighboring gene FYVE, RhoGEF and PH domain containing 3 Neighboring gene uncharacterized LOC134482823 Neighboring gene sushi domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in BICD2, which encodes a golgin and important motor adaptor, cause congenital autosomal-dominant spinal muscular atrophy. Neveling K, et al. Am J Hum Genet, 2013 Jun 6. PMID 23664116, Free PMC Article
    2. A role for Bicaudal-D2 in radial cerebellar granule cell migration. Jaarsma D, et al. Nat Commun, 2014 Mar 11. PMID 24614806
    3. Reconstitution of the targeting of Rab6A to the Golgi apparatus in semi-intact HeLa cells: A role of BICD2 in stabilizing Rab6A on Golgi membranes and a concerted role of Rab6A/BICD2 interactions in Golgi-to-ER retrograde transport. Matsuto M, et al. Biochim Biophys Acta, 2015 Oct. PMID 25962623
    4. Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry. Splinter D, et al. PLoS Biol, 2010 Apr 6. PMID 20386726, Free PMC Article
    5. Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. Matanis T, et al. Nat Cell Biol, 2002 Dec. PMID 12447383

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytoskeletal anchor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynactin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynactin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dynein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in centrosome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule anchoring at microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule anchoring at microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule-based movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in minus-end-directed organelle transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in annulate lamellae ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein bicaudal D homolog 2
    Names
    bicaudal D homolog 2
    bicaudal D protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033674.2 → NP_001028846.1  protein bicaudal D homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_001028846.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8J8Y893, Q496Z1
      Related
      ENSRNOP00000110082.1, ENSRNOT00000151003.1
      Conserved Domains (3) summary
      pfam09730
      Location:83 → 797
      BicD; Microtubule-associated protein Bicaudal-D
      cl19219
      Location:55 → 169
      DUF342; Protein of unknown function (DUF342)
      cl19252
      Location:178 → 230
      MreC; rod shape-determining protein MreC

    2. NM_198765.3 → NP_942060.1  protein bicaudal D homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_942060.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses alternate splice sites in the 3' coding region and differs in the 3' UTR compared to variant 1. It encodes isoform 2, which has a shorter C-terminus than isoform 1.
      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8J8Y893, F7FC29, Q712J3
      Related
      ENSRNOP00000047890.6, ENSRNOT00000048653.6
      Conserved Domains (3) summary
      pfam09730
      Location:83 → 797
      BicD; Microtubule-associated protein Bicaudal-D
      cl19219
      Location:55 → 169
      DUF342; Protein of unknown function (DUF342)
      cl19252
      Location:178 → 230
      MreC; rod shape-determining protein MreC

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      15449011..15511423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_010058861.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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