Orc1 origin recognition complex, subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Orc1provided by RGD
Official Full Name: origin recognition complex, subunit 1provided by RGD
Primary source: RGD:631435
See related: EnsemblRapid:ENSRNOG00000008841 AllianceGenome:RGD:631435
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Orc1l
Summary: Enables chromatin binding activity. Involved in positive regulation of G0 to G1 transition and positive regulation of smooth muscle cell proliferation. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be part of nuclear origin of replication recognition complex. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 1. Orthologous to human ORC1 (origin recognition complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 55.4), Spleen (RPKM 48.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q34

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (128552975..128581943)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (123324273..123348375)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (128186651..128212901)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ORC1 gene silencing causes rat VSMCs to enter a reversible G(0) quiescent, growth arrested state; thus, ORC1 gene may be an important new target for suppressing VSMCs proliferation.
Title: RNA interference targeting ORC1 gene suppresses the proliferation of vascular smooth muscle cells in rats.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA replication origin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication initiation	IEA Inferred from Electronic Annotation more info
involved_in DNA replication initiation	ISO Inferred from Sequence Orthology more info
involved_in mitotic DNA replication checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G0 to G1 transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
part_of nuclear origin of replication recognition complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear origin of replication recognition complex	IEA Inferred from Electronic Annotation more info
part_of nuclear origin of replication recognition complex	ISO Inferred from Sequence Orthology more info
part_of nuclear origin of replication recognition complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of origin recognition complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: origin recognition complex subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177931.2 → NP_808792.1 origin recognition complex subunit 1

See identical proteins and their annotated locations for NP_808792.1

Status: PROVISIONAL

Source sequence(s)

AB105378

UniProtKB/Swiss-Prot

Q80Z32

UniProtKB/TrEMBL

A0A8I6A918

Conserved Domains (5) summary

cd04719
Location:43 → 169

BAH_Orc1p_animal; BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC ...

TIGR02928
Location:482 → 814

TIGR02928; orc1/cdc6 family replication initiation protein

pfam09079
Location:765 → 838

Cdc6_C; CDC6, C terminal

pfam13191
Location:491 → 541

AAA_16; AAA ATPase domain

cl21455
Location:517 → 662

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

128552975..128581943

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238515.5 → XP_006238577.1 origin recognition complex subunit 1 isoform X1

See identical proteins and their annotated locations for XP_006238577.1

UniProtKB/TrEMBL

A0A8I6A918, A6JYV4

Related

ENSRNOP00000012492.7, ENSRNOT00000012492.8

Conserved Domains (5) summary

cd04719
Location:43 → 169

BAH_Orc1p_animal; BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC ...

TIGR02928
Location:482 → 814

TIGR02928; orc1/cdc6 family replication initiation protein

pfam09079
Location:765 → 838

Cdc6_C; CDC6, C terminal

pfam13191
Location:491 → 541

AAA_16; AAA ATPase domain

cl21455
Location:517 → 662

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_063287715.1 → XP_063143785.1 origin recognition complex subunit 1 isoform X3
XM_039109968.2 → XP_038965896.2 origin recognition complex subunit 1 isoform X2

UniProtKB/TrEMBL

G3V768