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    Btg2 BTG anti-proliferation factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29619, updated on 9-Dec-2024

    Summary

    Official Symbol
    Btg2provided by RGD
    Official Full Name
    BTG anti-proliferation factor 2provided by RGD
    Primary source
    RGD:2225
    See related
    EnsemblRapid:ENSRNOG00000003300 AllianceGenome:RGD:2225
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    An; Agl; Pc3; an-1; Tis21
    Summary
    Enables transcription corepressor activity. Involved in several processes, including cellular response to phorbol 13-acetate 12-myristate; negative regulation of neuron apoptotic process; and response to electrical stimulus. Acts upstream of or within negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; and neuron differentiation. Predicted to be active in cytoplasm and nucleus. Biomarker of acute necrotizing pancreatitis and brain ischemia. Orthologous to human BTG2 (BTG anti-proliferation factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 1207.6), Spleen (RPKM 360.3) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Btg2 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (48083931..48087690, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (45531881..45535642, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (50913185..50916944, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481559 Neighboring gene uncharacterized LOC134481558 Neighboring gene uncharacterized LOC120096251 Neighboring gene fibromodulin Neighboring gene chitinase 1 Neighboring gene uncharacterized LOC102552406

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 26
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response  
    acts_upstream_of_or_within anterior/posterior pattern specification  
    acts_upstream_of_or_within associative learning  
    involved_in cellular response to phorbol 13-acetate 12-myristate PubMed 
    acts_upstream_of_or_within central nervous system neuron development  
    acts_upstream_of_or_within dentate gyrus development  
    acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    acts_upstream_of_or_within negative regulation of neuroblast proliferation  
    involved_in negative regulation of neuron apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of translation  
    involved_in negative regulation of translation  
    acts_upstream_of neural precursor cell proliferation  
    acts_upstream_of neuroblast proliferation  
    acts_upstream_of_or_within neuron differentiation PubMed 
    involved_in neuron differentiation PubMed 
    involved_in neuron projection development  
    acts_upstream_of_or_within positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  
    acts_upstream_of_or_within protein methylation  
    involved_in response to electrical stimulus PubMed 
    involved_in response to mechanical stimulus PubMed 
    involved_in response to peptide hormone PubMed 
    acts_upstream_of_or_within skeletal muscle cell differentiation  
    Items 1 - 25 of 26
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in nucleus  

    General protein information

    Preferred Names
    protein BTG2
    Names
    B-cell translocation gene 2, anti-proliferative
    BTG family, member 2
    Early induced gene B-cell translocation gene 2
    NGF-inducible anti-proliferative protein PC3
    NGF-inducible anti-proliferative putative secreted protein
    cell surface alloantigen

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017259.2NP_058955.1  protein BTG2

      See identical proteins and their annotated locations for NP_058955.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      P27049
      UniProtKB/TrEMBL
      A6ICA3
      Related
      ENSRNOP00000004408.1, ENSRNOT00000004408.5
      Conserved Domains (1) summary
      pfam07742
      Location:9122
      BTG; BTG family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      48083931..48087690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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