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    Dlgap1 DLG associated protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65040, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dlgap1provided by RGD
    Official Full Name
    DLG associated protein 1provided by RGD
    Primary source
    RGD:620223
    See related
    EnsemblRapid:ENSRNOG00000016196 AllianceGenome:RGD:620223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gkap; DAP-1; rGKAP; SAPAP1; GKAP/SAPAP1
    Summary
    Enables protein domain specific binding activity. A structural constituent of postsynaptic density. Involved in several processes, including aggresome assembly; protein localization to synapse; and regulation of proteasomal protein catabolic process. Located in postsynaptic membrane. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human DLGAP1 (DLG associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 171.0), Lung (RPKM 19.0) and 4 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dlgap1 in Genome Data Viewer
    Location:
    9q38
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (117304144..118173463)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (109857500..110726817)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (118277046..119159807)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480431 Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene A-kinase anchor inhibitor 1 Neighboring gene uncharacterized LOC134480625 Neighboring gene dephospho-CoA kinase domain-containing protein-like Neighboring gene uncharacterized LOC120094814 Neighboring gene uncharacterized LOC102555426 Neighboring gene uncharacterized LOC134480624 Neighboring gene uncharacterized LOC102555570 Neighboring gene uncharacterized LOC120094777 Neighboring gene TGFB-induced factor homeobox 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in glutamatergic synapse  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in plasma membrane  
    located_in postsynaptic density  
    located_in postsynaptic density  
    is_active_in postsynaptic density, intracellular component PubMed 
    located_in postsynaptic membrane PubMed 
    is_active_in postsynaptic specialization  
    located_in synapse PubMed 
    located_in synapse  

    General protein information

    Preferred Names
    disks large-associated protein 1
    Names
    PSD-95 binding protein
    PSD-95/SAP90-binding protein 1
    SAP90/PSD-95-associated protein 1
    discs large homolog associated protein 1
    guanylate kinase-associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304287.1NP_001291216.1  disks large-associated protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks three 5' exons, contains an alternate 5' terminal exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AE66
      Related
      ENSRNOP00000072852.1, ENSRNOT00000087592.3
      Conserved Domains (1) summary
      pfam03359
      Location:360692
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    2. NM_022946.3NP_075235.3  disks large-associated protein 1 isoform 1

      See identical proteins and their annotated locations for NP_075235.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      O54773, P97836, P97841
      UniProtKB/TrEMBL
      A0A0G2K6T7, A6KF81
      Related
      ENSRNOP00000073938.1, ENSRNOT00000090512.4
      Conserved Domains (1) summary
      pfam03359
      Location:660992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      117304144..118173463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084190.2XP_038940118.1  disks large-associated protein 1 isoform X3

      UniProtKB/Swiss-Prot
      O54773, P97836, P97841
      Conserved Domains (1) summary
      pfam03359
      Location:632964
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    2. XM_039084191.2XP_038940119.1  disks large-associated protein 1 isoform X4

      UniProtKB/Swiss-Prot
      O54773, P97836, P97841
      UniProtKB/TrEMBL
      A6KF82
      Conserved Domains (1) summary
      pfam03359
      Location:622954
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    3. XM_039084189.2XP_038940117.1  disks large-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O54773, P97836, P97841
      UniProtKB/TrEMBL
      A0A0G2K6T7, A6KF81
      Conserved Domains (1) summary
      pfam03359
      Location:660992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    4. XM_039084188.2XP_038940116.1  disks large-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O54773, P97836, P97841
      UniProtKB/TrEMBL
      A0A0G2K6T7, A6KF81
      Conserved Domains (1) summary
      pfam03359
      Location:660992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    5. XM_017596627.3XP_017452116.1  disks large-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O54773, P97836, P97841
      UniProtKB/TrEMBL
      A0A0G2K6T7, A6KF81
      Conserved Domains (1) summary
      pfam03359
      Location:660992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    6. XM_017596630.3XP_017452119.1  disks large-associated protein 1 isoform X2

      UniProtKB/Swiss-Prot
      O54773, P97836, P97841
      UniProtKB/TrEMBL
      G3V849
      Related
      ENSRNOP00000022351.8, ENSRNOT00000022351.10
    7. XM_063267696.1XP_063123766.1  disks large-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O54773, P97836, P97841
      UniProtKB/TrEMBL
      A0A0G2K6T7, A6KF81
    8. XM_017596628.3XP_017452117.1  disks large-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O54773, P97836, P97841
      UniProtKB/TrEMBL
      A0A0G2K6T7, A6KF81
      Conserved Domains (1) summary
      pfam03359
      Location:660992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    9. XM_063267703.1XP_063123773.1  disks large-associated protein 1 isoform X17

      UniProtKB/TrEMBL
      A0A8I5ZYB2
    10. XM_063267701.1XP_063123771.1  disks large-associated protein 1 isoform X15

      UniProtKB/TrEMBL
      A0A8I5ZYB2
    11. XM_039084192.2XP_038940120.1  disks large-associated protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZYB2
      Conserved Domains (1) summary
      pfam03359
      Location:341673
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    12. XM_063267697.1XP_063123767.1  disks large-associated protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZYB2
    13. XM_008767429.4XP_008765651.1  disks large-associated protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZYB2
      Related
      ENSRNOP00000084169.2, ENSRNOT00000110426.2
      Conserved Domains (1) summary
      pfam03359
      Location:379711
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    14. XM_063267704.1XP_063123774.1  disks large-associated protein 1 isoform X18

      UniProtKB/TrEMBL
      A0A8I6AE66
    15. XM_063267700.1XP_063123770.1  disks large-associated protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZYB2
    16. XM_063267702.1XP_063123772.1  disks large-associated protein 1 isoform X16

      UniProtKB/TrEMBL
      A0A8I6AE66
    17. XM_039084193.2XP_038940121.1  disks large-associated protein 1 isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZYB2, A6KF84
      Conserved Domains (1) summary
      pfam03359
      Location:334666
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    18. XM_063267699.1XP_063123769.1  disks large-associated protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A8I6AE66
    19. XM_008767430.4XP_008765652.1  disks large-associated protein 1 isoform X7

      See identical proteins and their annotated locations for XP_008765652.1

      UniProtKB/TrEMBL
      A0A8I6AE66, A6KF83
      Conserved Domains (1) summary
      pfam03359
      Location:362694
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    20. XM_017596631.3XP_017452120.1  disks large-associated protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I6AE66
    21. XM_008767432.4XP_008765654.1  disks large-associated protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AE66
      Related
      ENSRNOP00000090776.2, ENSRNOT00000119591.2
      Conserved Domains (1) summary
      pfam03359
      Location:352684
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    22. XM_008767433.4XP_008765655.1  disks large-associated protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A8I6AE66
      Conserved Domains (1) summary
      pfam03359
      Location:341673
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
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