Dhrsx dehydrogenase/reductase X-linked [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dhrsxprovided by RGD
Official Full Name: dehydrogenase/reductase X-linkedprovided by RGD
Primary source: RGD:1305017
See related: EnsemblRapid:ENSRNOG00000028323 AllianceGenome:RGD:1305017
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable oxidoreductase activity. Predicted to be involved in positive regulation of autophagy. Predicted to be active in extracellular region. Orthologous to human DHRSX (dehydrogenase/reductase X-linked). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 105.2), Thymus (RPKM 94.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (21413563..21418319)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (16299768..16304553)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (18516858..18521235)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dolichal reductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables polyprenol dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in dolichol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in lipid droplet	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dehydrogenase/reductase SDR family member on chromosome X

Names: dehydrogenase/reductase (SDR family) X chromosome; dehydrogenase/reductase (SDR family) X-linked

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105914.2 → NP_001099384.2 dehydrogenase/reductase SDR family member on chromosome X isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A6K200
NM_001400919.1 → NP_001387848.1 dehydrogenase/reductase SDR family member on chromosome X isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A0A8J8YGQ6, B2RZ76, E9PTT7

Related

ENSRNOP00000031241.7, ENSRNOT00000029485.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

21413563..21418319

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006248995.5 → XP_006249057.1 dehydrogenase/reductase SDR family member on chromosome X isoform X2

Conserved Domains (1) summary

cl21454
Location:41 → 187

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_039089192.2 → XP_038945120.1 dehydrogenase/reductase SDR family member on chromosome X isoform X4

Conserved Domains (1) summary

cl21454
Location:41 → 187

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_017598292.3 → XP_017453781.1 dehydrogenase/reductase SDR family member on chromosome X isoform X1

UniProtKB/TrEMBL

B2RZ76, E9PTT7
XM_063271142.1 → XP_063127212.1 dehydrogenase/reductase SDR family member on chromosome X isoform X3