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    Kifc3 kinesin family member C3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307644, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kifc3provided by RGD
    Official Full Name
    kinesin family member C3provided by RGD
    Primary source
    RGD:1307693
    See related
    EnsemblRapid:ENSRNOG00000014087 AllianceGenome:RGD:1307693
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    KRP4
    Summary
    Predicted to enable identical protein binding activity and microtubule binding activity. Predicted to be involved in epithelial cell-cell adhesion; microtubule-based process; and zonula adherens maintenance. Predicted to act upstream of or within Golgi organization. Predicted to be located in several cellular components, including Golgi apparatus; centrosome; and zonula adherens. Predicted to be part of kinesin complex. Predicted to be active in microtubule cytoskeleton. Orthologous to human KIFC3 (kinesin family member C3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 88.0), Adrenal (RPKM 44.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kifc3 in Genome Data Viewer
    Location:
    19p13
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (9831159..9926405)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (9825114..9920371)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (10305405..10339186)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene sperm microtubule inner protein 8 Neighboring gene cyclic nucleotide gated channel subunit beta 1 Neighboring gene RNA, U2 small nuclear 69, pseudogene Neighboring gene uncharacterized LOC134483686 Neighboring gene katanin regulatory subunit B1 Neighboring gene dynein regulatory complex subunit 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Role of KIFC3 motor protein in Golgi positioning and integration. Xu Y, et al. J Cell Biol, 2002 Jul 22. PMID 12135985, Free PMC Article
    2. Kinesin-related proteins in the mammalian testes: candidate motors for meiosis and morphogenesis. Sperry AO, et al. Mol Biol Cell, 1996 Feb. PMID 8688559, Free PMC Article
    3. Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. Meng W, et al. Cell, 2008 Nov 28. PMID 19041755
    4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156699

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule-based process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in zonula adherens maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of kinesin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in zonula adherens ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIFC3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001103352.1 → NP_001096822.1  kinesin-like protein KIFC3 isoform 2

      See identical proteins and their annotated locations for NP_001096822.1

      Status: PROVISIONAL

      Source sequence(s)
      BC128748
      UniProtKB/TrEMBL
      A0A8I6A4I8, A1A5P4
      Conserved Domains (3) summary
      cd01366
      Location:370 → 697
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      pfam00225
      Location:378 → 695
      Kinesin; Kinesin motor domain
      cl12013
      Location:108 → 233
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. NM_001401191.1 → NP_001388120.1  kinesin-like protein KIFC3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I6ADV7
      Related
      ENSRNOP00000080196.2, ENSRNOT00000104498.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      9831159..9926405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097698.1 → XP_038953626.1  kinesin-like protein KIFC3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADV7
      Conserved Domains (2) summary
      COG1196
      Location:231 → 548
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01366
      Location:598 → 925
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    2. XM_017601265.2 → XP_017456754.2  kinesin-like protein KIFC3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ADV7
      Conserved Domains (2) summary
      COG1196
      Location:230 → 547
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01366
      Location:597 → 924
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    3. XM_063277982.1 → XP_063134052.1  kinesin-like protein KIFC3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ADV7

    4. XM_039097699.1 → XP_038953627.1  kinesin-like protein KIFC3 isoform X6

      UniProtKB/TrEMBL
      F7EXA8
      Conserved Domains (2) summary
      TIGR02168
      Location:179 → 488
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01366
      Location:491 → 818
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    5. XM_017601270.2 → XP_017456759.2  kinesin-like protein KIFC3 isoform X7

      UniProtKB/TrEMBL
      F7EXA8
      Related
      ENSRNOP00000094247.2, ENSRNOT00000107028.2
      Conserved Domains (2) summary
      TIGR02168
      Location:179 → 488
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01366
      Location:491 → 818
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    6. XM_017601266.3 → XP_017456755.2  kinesin-like protein KIFC3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ADV7
      Conserved Domains (2) summary
      COG1196
      Location:231 → 548
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01366
      Location:598 → 925
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    7. XM_017601269.3 → XP_017456758.2  kinesin-like protein KIFC3 isoform X5

      UniProtKB/TrEMBL
      A0A8I6ADV7
      Related
      ENSRNOP00000092397.1, ENSRNOT00000095742.2
      Conserved Domains (2) summary
      COG1196
      Location:231 → 548
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01366
      Location:598 → 925
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    8. XM_039097701.2 → XP_038953629.1  kinesin-like protein KIFC3 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AKJ1
      Conserved Domains (3) summary
      TIGR02168
      Location:93 → 402
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01366
      Location:405 → 732
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      pfam08317
      Location:26 → 150
      Spc7; Spc7 kinetochore protein

    9. XM_039097700.2 → XP_038953628.1  kinesin-like protein KIFC3 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AKJ1
      Conserved Domains (3) summary
      TIGR02168
      Location:93 → 402
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01366
      Location:405 → 732
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      pfam08317
      Location:26 → 150
      Spc7; Spc7 kinetochore protein

    10. XM_063277983.1 → XP_063134053.1  kinesin-like protein KIFC3 isoform X9

      UniProtKB/TrEMBL
      A0A8I6AKJ1

    11. XM_008772292.4 → XP_008770514.2  kinesin-like protein KIFC3 isoform X9

      UniProtKB/TrEMBL
      A0A8I6AKJ1
      Conserved Domains (2) summary
      TIGR02168
      Location:58 → 367
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01366
      Location:370 → 697
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    12. XM_008772293.3 → XP_008770515.2  kinesin-like protein KIFC3 isoform X10

      UniProtKB/TrEMBL
      A0A8I6AKJ1
      Related
      ENSRNOP00000085654.2, ENSRNOT00000093890.2
      Conserved Domains (2) summary
      TIGR02168
      Location:49 → 358
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01366
      Location:361 → 688
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    13. XM_063277984.1 → XP_063134054.1  kinesin-like protein KIFC3 isoform X11

      UniProtKB/TrEMBL
      A0A8I6A4I8

    RNA

    1. XR_005496646.2 RNA Sequence

    2. XR_005496647.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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