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    Adgrd1 adhesion G protein-coupled receptor D1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689257, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adgrd1provided by RGD
    Official Full Name
    adhesion G protein-coupled receptor D1provided by RGD
    Primary source
    RGD:1594795
    See related
    EnsemblRapid:ENSRNOG00000023536 AllianceGenome:RGD:1594795
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gpr133
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in cytosol and nuclear speck. Predicted to be active in plasma membrane. Orthologous to human ADGRD1 (adhesion G protein-coupled receptor D1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 27.6), Muscle (RPKM 16.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adgrd1 in Genome Data Viewer
    Location:
    12q13
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (33124981..33239778, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (27488908..27603714, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (31134806..31249594, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555340 Neighboring gene uncharacterized LOC134481332 Neighboring gene uncharacterized LOC134481179 Neighboring gene uncharacterized LOC120095936 Neighboring gene uncharacterized LOC120095937

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cell adhesion receptor GPR133 couples to Gs protein. Bohnekamp J, et al. J Biol Chem, 2011 Dec 9. PMID 22025619, Free PMC Article
    2. A tethered agonist within the ectodomain activates the adhesion G protein-coupled receptors GPR126 and GPR133. Liebscher I, et al. Cell Rep, 2014 Dec 24. PMID 25533341, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor D1; adhesion G-protein coupled receptor D1
    Names
    G protein-coupled receptor 133

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432114.1 → NP_001419043.1  adhesion G protein-coupled receptor D1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      D3ZF17

    2. NM_001432115.1 → NP_001419044.1  adhesion G protein-coupled receptor D1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      M0RAV7

    3. NM_001432116.1 → NP_001419045.1  adhesion G protein-coupled receptor D1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      33124981..33239778 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598511.3 → XP_017454000.1  adhesion G-protein coupled receptor D1 isoform X2

      Related
      ENSRNOP00000066668.1, ENSRNOT00000073105.3
      Conserved Domains (3) summary
      pfam01825
      Location:507 → 547
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:563 → 799
      7tm_4; Olfactory receptor
      cl22861
      Location:141 → 241
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    2. XM_001070157.9 → XP_001070157.3  adhesion G-protein coupled receptor D1 isoform X1

      Related
      ENSRNOP00000055384.3, ENSRNOT00000058586.7
      Conserved Domains (3) summary
      pfam01825
      Location:539 → 579
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:595 → 831
      7tm_4; Olfactory receptor
      cl22861
      Location:173 → 273
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    3. XM_063271783.1 → XP_063127853.1  adhesion G-protein coupled receptor D1 isoform X4

    4. XM_039090099.2 → XP_038946027.1  adhesion G-protein coupled receptor D1 isoform X3

      Conserved Domains (4) summary
      smart00303
      Location:537 → 584
      GPS; G-protein-coupled receptor proteolytic site domain
      cd14964
      Location:594 → 619
      7tm_GPCRs; TM helix 1 [structural motif]
      cl22861
      Location:175 → 273
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl28897
      Location:592 → 720
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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