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    Serpina3c serine (or cysteine) proteinase inhibitor, clade A, member 3C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24794, updated on 27-Dec-2024

    Summary

    Official Symbol
    Serpina3cprovided by RGD
    Official Full Name
    serine (or cysteine) proteinase inhibitor, clade A, member 3Cprovided by RGD
    Primary source
    RGD:2972
    See related
    EnsemblRapid:ENSRNOG00000010410 AllianceGenome:RGD:2972
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kbp; SPI2; Klkbp; SPI-2; Spin2; CPi-21; Spin2b; GHR-P63; SPI-2.3; Serpina3k
    Summary
    Involved in negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; and positive regulation of apoptotic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 23764.1) See more
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    Genomic context

    See Serpina3c in Genome Data Viewer
    Location:
    6q32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (129007578..129014988, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (123240251..123250219, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (127996162..128003433, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3A Neighboring gene serine protease inhibitor A3B-like Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3L Neighboring gene serpin family A member 3N

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in extracellular space  

    General protein information

    Preferred Names
    serine protease inhibitor A3K
    Names
    contrapsin-like protease inhibitor 1
    growth hormone-regulated proteinase inhibitor
    kallikrein-binding protein
    kallistatin
    serine (or cysteine) peptidase inhibitor, clade A, member 3K
    serine protease inhibitor 2
    serine protease inhibitor 2b
    serpin A3K
    thyroid hormone-regulated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012657.2NP_036789.2  serine protease inhibitor A3K precursor

      See identical proteins and their annotated locations for NP_036789.2

      Status: VALIDATED

      Source sequence(s)
      BC062236, CO560755, JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P05545, P14281, Q64254, Q6P6G8
      UniProtKB/TrEMBL
      A0A0G2JSK1, A6JEQ6
      Conserved Domains (1) summary
      smart00093
      Location:54415
      SERPIN; SERine Proteinase INhibitors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      129007578..129014988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240458.5XP_006240520.1  serine protease inhibitor A3K isoform X1

      See identical proteins and their annotated locations for XP_006240520.1

      UniProtKB/Swiss-Prot
      P05545, P14281, Q64254, Q6P6G8
      UniProtKB/TrEMBL
      A0A0G2JSK1, A6JEQ6
      Related
      ENSRNOP00000013896.2, ENSRNOT00000013896.6
      Conserved Domains (1) summary
      smart00093
      Location:54415
      SERPIN; SERine Proteinase INhibitors
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