Arl6ip5 ARF like GTPase 6 interacting protein 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arl6ip5provided by RGD
Official Full Name: ARF like GTPase 6 interacting protein 5provided by RGD
Primary source: RGD:708572
See related: EnsemblRapid:ENSRNOG00000006818 AllianceGenome:RGD:708572
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gtrap3-18
Summary: Enables transmembrane transporter binding activity. Involved in negative regulation of transport and regulation of neurotransmitter uptake. Predicted to be located in cytoskeleton and endoplasmic reticulum membrane. Predicted to be active in plasma membrane and presynaptic cytosol. Orthologous to human ARL6IP5 (ADP ribosylation factor like GTPase 6 interacting protein 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 805.0), Heart (RPKM 719.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (131365320..131395311)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (129810650..129838628)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (129574363..129598240)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These observations suggest that JWA is directly involved in the regulation of chronic morphine dependence.
Title: JWA regulates chronic morphine dependence via the delta opioid receptor.
Results suggest a model where protein trafficking and neuronal differentiation are directly linked by the interaction of Rab1 and its regulator GTRAP3-18.
Title: GTRAP3-18 serves as a negative regulator of Rab1 in protein transport and neuronal differentiation.
The expression and distribution of the neuronal glutamate transporter, excitatory amino acid carrier-1 (EAAC1), are demonstrated in the dorsal root ganglion neurons and their central terminals.
Title: Evidence of neuronal excitatory amino acid carrier 1 expression in rat dorsal root ganglion neurons and their central terminals.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in L-glutamate import across plasma membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_negative_effect L-glutamate import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within L-glutamate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in cellular response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in glutathione metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glutathione metabolic process	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within learning or memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of L-glutamate import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of L-glutamate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of L-glutamate import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mitochondrial membrane potential	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_negative_effect protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter uptake	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neurotransmitter uptake	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic cytosol	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: PRA1 family protein 3

Names: ADP-ribosylation factor like GTPase 6 interacting protein 5; ADP-ribosylation factor-like 6 interacting protein 5; ADP-ribosylation factor-like protein 6-interacting protein 5; ADP-ribosylation-like factor 6 interacting protein 5; ARL-6-interacting protein 5; aip-5; glutamate transporter EAAC1-interacting protein; prenylated Rab acceptor protein 2; protein JWa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023972.4 → NP_076462.1 PRA1 family protein 3

See identical proteins and their annotated locations for NP_076462.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q9ES40, Q9JKD1

UniProtKB/TrEMBL

A0A0H2UHF6, A6IBF8

Related

ENSRNOP00000106824.1, ENSRNOT00000154970.1

Conserved Domains (1) summary

pfam03208
Location:3 → 148

PRA1; PRA1 family protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

131365320..131395311

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286671.1 → XP_063142741.1 PRA1 family protein 3 isoform X1

UniProtKB/Swiss-Prot

Q9ES40, Q9JKD1

UniProtKB/TrEMBL

A0A0H2UHF6, A6IBF8
XM_063286670.1 → XP_063142740.1 PRA1 family protein 3 isoform X1

UniProtKB/Swiss-Prot

Q9ES40, Q9JKD1

UniProtKB/TrEMBL

A0A0H2UHF6, A6IBF8

Related

ENSRNOP00000010185.5, ENSRNOT00000010185.8
XM_039108327.2 → XP_038964255.1 PRA1 family protein 3 isoform X1

UniProtKB/Swiss-Prot

Q9ES40, Q9JKD1

UniProtKB/TrEMBL

A0A0H2UHF6, A6IBF8

Conserved Domains (1) summary

pfam03208
Location:3 → 148

PRA1; PRA1 family protein
XM_039108328.2 → XP_038964256.1 PRA1 family protein 3 isoform X1

UniProtKB/Swiss-Prot

Q9ES40, Q9JKD1

UniProtKB/TrEMBL

A0A0H2UHF6, A6IBF8

Conserved Domains (1) summary

pfam03208
Location:3 → 148

PRA1; PRA1 family protein