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    Cox7b cytochrome c oxidase subunit 7B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303393, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cox7bprovided by RGD
    Official Full Name
    cytochrome c oxidase subunit 7Bprovided by RGD
    Primary source
    RGD:727789
    See related
    EnsemblRapid:ENSRNOG00000054689 AllianceGenome:RGD:727789
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in central nervous system development. Predicted to be located in mitochondrial membrane. Predicted to be part of respiratory chain complex IV. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 2. Orthologous to human COX7B (cytochrome c oxidase subunit 7B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 9705.5), Muscle (RPKM 5890.5) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cox7b in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (75149036..75155285)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (71083486..71089733)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (77065427..77071676)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene GC-rich promoter binding protein 1, pseudogene 1 Neighboring gene magnesium transporter 1 Neighboring gene ATPase copper transporting alpha Neighboring gene toll-like receptor 13

    Genomic regions, transcripts, and products

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in central nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in central nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cytochrome c oxidase subunit 7B, mitochondrial
    Names
    cytochrome c oxidase polypeptide VIIb
    cytochrome c oxidase subunit VIIb
    NP_877971.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182819.2NP_877971.2  cytochrome c oxidase subunit 7B, mitochondrial precursor

      See identical proteins and their annotated locations for NP_877971.2

      Status: PROVISIONAL

      Source sequence(s)
      BC079123
      UniProtKB/Swiss-Prot
      P80431, Q6AYA9, Q7TPH1
      UniProtKB/TrEMBL
      A6IV38
      Related
      ENSRNOP00000074109.1, ENSRNOT00000090007.3
      Conserved Domains (1) summary
      pfam05392
      Location:179
      COX7B; Cytochrome C oxidase chain VIIB

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      75149036..75155285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)