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    Pnpla2 patatin-like phospholipase domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361676, updated on 9-Dec-2024

    Summary

    Symbol
    Pnpla2provided by RGD
    Full Name
    patatin-like phospholipase domain containing 2provided by RGD
    Primary source
    RGD:1309044
    See related
    EnsemblRapid:ENSRNOG00000069673 AllianceGenome:RGD:1309044
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309044
    Summary
    Predicted to enable acylglycerol O-acyltransferase activity and carboxylic ester hydrolase activity. Predicted to be involved in several processes, including acylglycerol metabolic process; intracellular triglyceride homeostasis; and lipid droplet disassembly. Predicted to act upstream of with a negative effect on lipid droplet fusion. Predicted to act upstream of or within cellular lipid catabolic process and lipid droplet organization. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm; lipid droplet; and membrane. Orthologous to human PNPLA2 (patatin like phospholipase domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 668.7), Adrenal (RPKM 610.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Pnpla2 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205982279..205987361)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196552723..196557805)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (214434638..214439720)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene p53-induced death domain protein 1 Neighboring gene ribosomal protein lateral stalk subunit P2 Neighboring gene small nucleolar RNA, H/ACA box 52 Neighboring gene calcium release activated channel regulator 2B Neighboring gene CD151 molecule (Raph blood group)

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acylglycerol O-acyltransferase activity  
    enables calcium-dependent phospholipase A2 activity  
    enables calcium-independent phospholipase A2 activity  
    enables diolein transacylation activity  
    enables diolein transacylation activity  
    enables mono-olein transacylation activity  
    enables mono-olein transacylation activity  
    enables phospholipase A2 activity  
    enables phospholipase A2 activity  
    enables protein binding PubMed 
    enables retinyl-palmitate esterase activity  
    enables retinyl-palmitate esterase activity  
    enables triacylglycerol lipase activity  
    enables triacylglycerol lipase activity  
    enables triacylglycerol lipase activity  
    enables triacylglycerol lipase activity  
    Process Evidence Code Pubs
    involved_in diacylglycerol biosynthetic process  
    involved_in diacylglycerol biosynthetic process  
    involved_in intracellular triglyceride homeostasis  
    involved_in intracellular triglyceride homeostasis  
    involved_in lipid catabolic process  
    involved_in lipid droplet disassembly  
    acts_upstream_of_negative_effect lipid droplet fusion  
    acts_upstream_of_negative_effect lipid droplet fusion  
    acts_upstream_of_or_within lipid droplet organization  
    involved_in lipid homeostasis  
    involved_in lipid storage  
    involved_in negative regulation of sequestering of triglyceride  
    involved_in negative regulation of sequestering of triglyceride  
    involved_in positive regulation of triglyceride catabolic process  
    involved_in positive regulation of triglyceride catabolic process  
    involved_in positive regulation of triglyceride catabolic process  
    involved_in retinol metabolic process  
    involved_in triglyceride catabolic process  
    involved_in triglyceride catabolic process  
    acts_upstream_of_or_within triglyceride catabolic process  
    involved_in triglyceride catabolic process  
    involved_in triglyceride catabolic process  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    is_active_in lipid droplet  
    is_active_in lipid droplet  
    located_in lipid droplet  
    is_active_in lipid droplet  
    located_in lipid droplet  
    is_active_in membrane  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in plasma membrane  

    General protein information

    Preferred Names
    patatin-like phospholipase domain-containing protein 2
    Names
    adipose triglyceride lipase
    calcium-independent phospholipase A2-zeta
    iPLA2-zeta
    patatin-like phospholipase domain-containing protein 2-like
    NP_001101979.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108509.2NP_001101979.2  patatin-like phospholipase domain-containing protein 2

      See identical proteins and their annotated locations for NP_001101979.2

      Status: VALIDATED

      Source sequence(s)
      AC109542, CK470716, CV120368, DW319842
      UniProtKB/Swiss-Prot
      P0C548
      UniProtKB/TrEMBL
      A0A8L2QDK4, A6HXY0, A6HXY1
      Related
      ENSRNOP00000025826.4, ENSRNOT00000025826.7
      Conserved Domains (1) summary
      cd07220
      Location:4252
      Pat_PNPLA2; Patatin-like phospholipase domain containing protein 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      205982279..205987361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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