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    Cherp calcium homeostasis endoplasmic reticulum protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290614, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cherpprovided by RGD
    Official Full Name
    calcium homeostasis endoplasmic reticulum proteinprovided by RGD
    Primary source
    RGD:1305279
    See related
    EnsemblRapid:ENSRNOG00000012323 AllianceGenome:RGD:1305279
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transmembrane transporter binding activity. Predicted to be involved in intracellular calcium ion homeostasis; positive regulation of calcineurin-NFAT signaling cascade; and release of sequestered calcium ion into cytosol. Predicted to act upstream of or within negative regulation of cell population proliferation. Located in sarcoplasmic reticulum membrane. Orthologous to human CHERP (calcium homeostasis endoplasmic reticulum protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 72.8), Thymus (RPKM 69.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cherp in Genome Data Viewer
    Location:
    16p14
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (17401497..17414549)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (17367455..17380507)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19068783..19081837)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 26 Neighboring gene uncharacterized LOC134482462 Neighboring gene solute carrier family 35, member E1 Neighboring gene similar to human chromosome 19 open reading frame 44 Neighboring gene calreticulin 3 Neighboring gene epidermal growth factor receptor pathway substrate 15-like 1 Neighboring gene KLF transcription factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of human Ca2+ homoeostasis endoplasmic reticulum protein (CHERP): regulated expression of antisense cDNA depletes CHERP, inhibits intracellular Ca2+ mobilization and decreases cell proliferation. Laplante JM, et al. Biochem J, 2000 May 15. PMID 10794731, Free PMC Article
    2. Identification of novel ryanodine receptor 1 (RyR1) protein interaction with calcium homeostasis endoplasmic reticulum protein (CHERP). Ryan T, et al. J Biol Chem, 2011 May 13. PMID 21454501, Free PMC Article
    3. Antisense-mediated loss of calcium homoeostasis endoplasmic reticulum protein (CHERP; ERPROT213-21) impairs Ca2+ mobilization, nuclear factor of activated T-cells (NFAT) activation and cell proliferation in Jurkat T-lymphocytes. O'Rourke FA, et al. Biochem J, 2003 Jul 1. PMID 12656674, Free PMC Article
    4. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
    5. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CHERP is an RyR1 interacting protein that may be involved in the regulation of excitation-contraction coupling
      Title: Identification of novel ryanodine receptor 1 (RyR1) protein interaction with calcium homeostasis endoplasmic reticulum protein (CHERP).
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calcium homeostasis endoplasmic reticulum protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106064.1 → NP_001099534.1  calcium homeostasis endoplasmic reticulum protein

      See identical proteins and their annotated locations for NP_001099534.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474031
      UniProtKB/TrEMBL
      A0A8I5ZN65, A6K9P2
      Related
      ENSRNOP00000087633.1, ENSRNOT00000110673.2
      Conserved Domains (3) summary
      smart00443
      Location:847 → 897
      G_patch; glycine rich nucleic binding domain
      smart00648
      Location:13 → 65
      SWAP; Suppressor-of-White-APricot splicing regulator
      pfam04818
      Location:212 → 271
      CTD_bind; RNA polymerase II-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      17401497..17414549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252796.5 → XP_006252858.1  calcium homeostasis endoplasmic reticulum protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZN65, D3ZAX5
      Conserved Domains (3) summary
      smart00443
      Location:858 → 908
      G_patch; glycine rich nucleic binding domain
      smart00648
      Location:13 → 65
      SWAP; Suppressor-of-White-APricot splicing regulator
      pfam04818
      Location:212 → 282
      CTD_bind; RNA polymerase II-binding domain

    2. XM_006252797.5 → XP_006252859.1  calcium homeostasis endoplasmic reticulum protein isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZN65
      Conserved Domains (3) summary
      smart00443
      Location:854 → 904
      G_patch; glycine rich nucleic binding domain
      smart00648
      Location:13 → 65
      SWAP; Suppressor-of-White-APricot splicing regulator
      pfam04818
      Location:212 → 282
      CTD_bind; RNA polymerase II-binding domain

    3. XM_039094273.2 → XP_038950201.1  calcium homeostasis endoplasmic reticulum protein isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZN65
      Related
      ENSRNOP00000017424.7, ENSRNOT00000017424.7
      Conserved Domains (4) summary
      PHA03377
      Location:386 → 695
      PHA03377; EBNA-3C; Provisional
      smart00443
      Location:852 → 902
      G_patch; glycine rich nucleic binding domain
      smart00648
      Location:13 → 65
      SWAP; Suppressor-of-White-APricot splicing regulator
      pfam04818
      Location:160 → 286
      CTD_bind; RNA polymerase II-binding domain

    4. XM_039094274.2 → XP_038950202.1  calcium homeostasis endoplasmic reticulum protein isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZN65
      Conserved Domains (4) summary
      PHA03377
      Location:381 → 690
      PHA03377; EBNA-3C; Provisional
      smart00443
      Location:843 → 893
      G_patch; glycine rich nucleic binding domain
      smart00648
      Location:13 → 65
      SWAP; Suppressor-of-White-APricot splicing regulator
      pfam04818
      Location:160 → 281
      CTD_bind; RNA polymerase II-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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