Plag1 PLAG1 zinc finger [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plag1provided by RGD
Official Full Name: PLAG1 zinc fingerprovided by RGD
Primary source: RGD:1305286
See related: EnsemblRapid:ENSRNOG00000008846 AllianceGenome:RGD:1305286
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of glial cell proliferation and regulation of gene expression. Predicted to act upstream of or within gland morphogenesis and prostate gland growth. Predicted to be located in centrosome; cytosol; and nuclear speck. Human ortholog(s) of this gene implicated in Silver-Russell syndrome and pleomorphic adenoma. Orthologous to human PLAG1 (PLAG1 zinc finger). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 55.5), Thymus (RPKM 48.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (21699650..21754325, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (16902057..16956727, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (16788186..16842827, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLAG1 Promotes High Glucose-Induced Angiogenesis and Migration of Retinal Endothelial Cells by Regulating the Wnt/beta-Catenin Signalling Pathway.
Title: PLAG1 Promotes High Glucose-Induced Angiogenesis and Migration of Retinal Endothelial Cells by Regulating the Wnt/β-Catenin Signalling Pathway.

Submit: New GeneRIF Correction

General gene information

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Markers

Plag1 (e-PCR), detects polymorphism
- UniSTS:472870

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within gland morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within organ growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostate gland growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger protein PLAG1

Names: pleiomorphic adenoma gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008316.2 → NP_001008317.1 zinc finger protein PLAG1

See identical proteins and their annotated locations for NP_001008317.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q5U2T6

UniProtKB/TrEMBL

A6JFM0

Related

ENSRNOP00000011721.3, ENSRNOT00000011721.6

Conserved Domains (3) summary

COG5189
Location:58 → 139

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:36 → 56

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:79 → 103

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

21699650..21754325 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008763525.4 → XP_008761747.1 zinc finger protein PLAG1 isoform X1

See identical proteins and their annotated locations for XP_008761747.1

UniProtKB/Swiss-Prot

Q5U2T6

UniProtKB/TrEMBL

A6JFM0

Conserved Domains (3) summary

COG5189
Location:58 → 139

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:36 → 56

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:79 → 103

zf-H2C2_2; Zinc-finger double domain
XM_063287277.1 → XP_063143347.1 zinc finger protein PLAG1 isoform X1

UniProtKB/Swiss-Prot

Q5U2T6

UniProtKB/TrEMBL

A6JFM0
XM_063287274.1 → XP_063143344.1 zinc finger protein PLAG1 isoform X1

UniProtKB/Swiss-Prot

Q5U2T6

UniProtKB/TrEMBL

A6JFM0
XM_063287275.1 → XP_063143345.1 zinc finger protein PLAG1 isoform X1

UniProtKB/Swiss-Prot

Q5U2T6

UniProtKB/TrEMBL

A6JFM0
XM_017593224.3 → XP_017448713.1 zinc finger protein PLAG1 isoform X2

Conserved Domains (2) summary

sd00017
Location:70 → 90

ZF_C2H2; C2H2 Zn finger [structural motif]

cd20908
Location:10 → 58

SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
XM_063287278.1 → XP_063143348.1 zinc finger protein PLAG1 isoform X2
XM_063287276.1 → XP_063143346.1 zinc finger protein PLAG1 isoform X1

UniProtKB/Swiss-Prot

Q5U2T6

UniProtKB/TrEMBL

A6JFM0