Tent2 terminal nucleotidyltransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tent2provided by RGD
Official Full Name: terminal nucleotidyltransferase 2provided by RGD
Primary source: RGD:1306438
See related: EnsemblRapid:ENSRNOG00000012099 AllianceGenome:RGD:1306438
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Papd4
Summary: Predicted to enable poly(A) RNA polymerase activity. Involved in several processes, including RNA polyadenylation at postsynapse; dark adaptation; and nervous system development. Is active in glutamatergic synapse; perforant pathway to dendrate granule cell synapse; and postsynapse. Orthologous to human TENT2 (terminal nucleotidyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 159.4), Thymus (RPKM 132.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q12

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (26115150..26167465, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (24380135..24432099, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (22746290..22798252, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

XRN2 and PAPD4 and are highly expressed in the retina and have distinct gene expression profiles during development.
Title: Developmental and functional expression of miRNA-stability related genes in the nervous system.
poly(A) polymerase Gld2, deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd) are components of a dendritic CPEB-associated polyadenylation apparatus
Title: Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables poly(A) RNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) RNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables poly(A) RNA polymerase activity	ISO Inferred from Sequence Orthology more info
enables poly(A) RNA polymerase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in RNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA polyadenylation at postsynapse	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA polyadenylation at postsynapse	IEP Inferred from Expression Pattern more info	PubMed
involved_in dark adaptation	IEP Inferred from Expression Pattern more info	PubMed
involved_in hematopoietic progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in histone mRNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in histone mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in histone mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA 3'-end processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in mRNA 3'-end processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of miRNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of miRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of miRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation at postsynapse	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translation at postsynapse	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of translation at postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retina development in camera-type eye	IEP Inferred from Expression Pattern more info	PubMed
involved_in target-directed miRNA degradation	IEA Inferred from Electronic Annotation more info
involved_in target-directed miRNA degradation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in perforant pathway to dendrate granule cell synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in perforant pathway to dendrate granule cell synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: poly(A) RNA polymerase GLD2

Names: PAP associated domain containing 4; PAP-associated domain-containing protein 4; poly(A) RNA polymerase D4, non-canonical

NP_001008373.1

EC 2.7.7.19

XP_006231840.1

EC 2.7.7.19

XP_038958452.1

EC 2.7.7.19

XP_038958453.1

EC 2.7.7.19

XP_038958454.1

EC 2.7.7.19

XP_038958456.1

EC 2.7.7.19

XP_063138096.1

EC 2.7.7.19

XP_063138097.1

EC 2.7.7.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008372.2 → NP_001008373.1 poly(A) RNA polymerase GLD2

See identical proteins and their annotated locations for NP_001008373.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q5U315

UniProtKB/TrEMBL

A6I4S9

Conserved Domains (1) summary

COG5260
Location:135 → 468

TRF4; DNA polymerase sigma [Replication, recombination and repair]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

26115150..26167465 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231778.4 → XP_006231840.1 poly(A) RNA polymerase GLD2 isoform X4

UniProtKB/TrEMBL

A0A8L2Q7L8

Related

ENSRNOP00000016135.5, ENSRNOT00000016135.8

Conserved Domains (2) summary

cd05402
Location:176 → 294

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

pfam03828
Location:382 → 436

PAP_assoc; Cid1 family poly A polymerase
XM_039102526.2 → XP_038958454.1 poly(A) RNA polymerase GLD2 isoform X2

Conserved Domains (1) summary

COG5260
Location:224 → 490

TRF4; DNA polymerase sigma [Replication, recombination and repair]
XM_039102524.2 → XP_038958452.1 poly(A) RNA polymerase GLD2 isoform X1

Conserved Domains (1) summary

COG5260
Location:224 → 494

TRF4; DNA polymerase sigma [Replication, recombination and repair]
XM_063282027.1 → XP_063138097.1 poly(A) RNA polymerase GLD2 isoform X4

UniProtKB/TrEMBL

A0A8L2Q7L8
XM_063282026.1 → XP_063138096.1 poly(A) RNA polymerase GLD2 isoform X3

UniProtKB/Swiss-Prot

Q5U315

UniProtKB/TrEMBL

A6I4S9
XM_039102525.2 → XP_038958453.1 poly(A) RNA polymerase GLD2 isoform X1

Conserved Domains (1) summary

COG5260
Location:224 → 494

TRF4; DNA polymerase sigma [Replication, recombination and repair]
XM_039102528.2 → XP_038958456.1 poly(A) RNA polymerase GLD2 isoform X5

Conserved Domains (1) summary

cd05402
Location:176 → 298

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases