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    Lpin1 lipin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313977, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lpin1provided by RGD
    Official Full Name
    lipin 1provided by RGD
    Primary source
    RGD:1307646
    See related
    EnsemblRapid:ENSRNOG00000004377 AllianceGenome:RGD:1307646
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including histone deacetylase binding activity; peroxisome proliferator activated receptor binding activity; and phosphatidate phosphatase activity. Involved in several processes, including cellular response to insulin stimulus; negative regulation of myelination; and negative regulation of phosphatidic acid biosynthetic process. Predicted to be located in cytoplasm and nuclear membrane. Predicted to be part of transcription regulator complex. Predicted to be active in several cellular components, including cytosol; endoplasmic reticulum membrane; and mitochondrial outer membrane. Biomarker of end stage renal disease. Orthologous to human LPIN1 (lipin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 247.8), Heart (RPKM 187.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Lpin1 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (45039110..45145845, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (39309198..39417034, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (41796214..41905149, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093236 Neighboring gene uncharacterized LOC102550954 Neighboring gene neurotensin receptor 2 Neighboring gene growth regulating estrogen receptor binding 1 Neighboring gene E2F transcription factor 6

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization  
    involved_in animal organ regeneration PubMed 
    involved_in cellular response to insulin stimulus  
    involved_in cellular response to insulin stimulus PubMed 
    acts_upstream_of_or_within cellular response to insulin stimulus  
    involved_in fatty acid catabolic process  
    involved_in fatty acid catabolic process  
    acts_upstream_of_or_within immune response  
    acts_upstream_of_or_within lipid metabolic process  
    involved_in mitochondrial fission  
    involved_in negative regulation of myelination PubMed 
    involved_in negative regulation of phosphatidic acid biosynthetic process PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in phosphatidic acid metabolic process  
    involved_in phosphatidylethanolamine metabolic process  
    involved_in positive regulation of cold-induced thermogenesis  
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of fat cell differentiation  
    acts_upstream_of_or_within ruffle organization  
    involved_in triglyceride biosynthetic process  
    involved_in triglyceride biosynthetic process  
    involved_in triglyceride mobilization  
    Component Evidence Code Pubs
    located_in cytoplasm  
    is_active_in cytosol  
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    is_active_in endoplasmic reticulum membrane  
    is_active_in mitochondrial outer membrane  
    located_in mitochondrial outer membrane  
    located_in nuclear membrane  
    is_active_in nucleus  
    located_in nucleus  
    part_of transcription regulator complex  

    General protein information

    Preferred Names
    phosphatidate phosphatase LPIN1
    NP_001012111.1
    XP_038968123.1
    XP_038968124.1
    XP_038968125.1
    XP_038968127.1
    XP_038968128.1
    XP_038968129.1
    XP_038968130.1
    XP_038968131.1
    XP_038968132.1
    XP_063117955.1
    XP_063117956.1
    XP_063117958.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012111.1NP_001012111.1  phosphatidate phosphatase LPIN1

      See identical proteins and their annotated locations for NP_001012111.1

      Status: VALIDATED

      Source sequence(s)
      BC083651
      UniProtKB/TrEMBL
      A6HAS7, Q5XIM8
      Related
      ENSRNOP00000005863.6, ENSRNOT00000005863.8
      Conserved Domains (4) summary
      pfam15017
      Location:889918
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:1106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:660885
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:498588
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      45039110..45145845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112199.2XP_038968127.1  phosphatidate phosphatase LPIN1 isoform X4

      UniProtKB/TrEMBL
      A6HAS7
      Conserved Domains (3) summary
      pfam04571
      Location:50156
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:708933
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:546637
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    2. XM_039112197.2XP_038968125.1  phosphatidate phosphatase LPIN1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JW03, A6HAS6, A6HAS7
      Conserved Domains (3) summary
      pfam04571
      Location:50156
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:709934
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:547638
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    3. XM_039112195.2XP_038968123.1  phosphatidate phosphatase LPIN1 isoform X1

      UniProtKB/TrEMBL
      A6HAS7
      Conserved Domains (3) summary
      pfam04571
      Location:50156
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:735960
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:547664
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    4. XM_039112200.2XP_038968128.1  phosphatidate phosphatase LPIN1 isoform X5

      UniProtKB/TrEMBL
      A6HAS7
      Conserved Domains (3) summary
      pfam04571
      Location:50156
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:702927
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:514631
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    5. XM_039112196.2XP_038968124.1  phosphatidate phosphatase LPIN1 isoform X2

      UniProtKB/TrEMBL
      A6HAS7
      Conserved Domains (3) summary
      pfam04571
      Location:50156
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:734959
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:546663
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    6. XM_039112203.2XP_038968131.1  phosphatidate phosphatase LPIN1 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZPU6, A6HAS7
      Related
      ENSRNOP00000080344.1, ENSRNOT00000114735.2
      Conserved Domains (3) summary
      pfam04571
      Location:50156
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:676901
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:514605
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    7. XM_063261885.1XP_063117955.1  phosphatidate phosphatase LPIN1 isoform X7

      UniProtKB/TrEMBL
      A6HAS7
    8. XM_039112201.2XP_038968129.1  phosphatidate phosphatase LPIN1 isoform X6

      UniProtKB/TrEMBL
      A6HAS7, F7FDH2
      Conserved Domains (3) summary
      pfam04571
      Location:1107
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:686911
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:498615
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    9. XM_039112202.2XP_038968130.1  phosphatidate phosphatase LPIN1 isoform X6

      UniProtKB/TrEMBL
      A6HAS7, F7FDH2
      Conserved Domains (3) summary
      pfam04571
      Location:1107
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:686911
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:498615
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    10. XM_063261888.1XP_063117958.1  phosphatidate phosphatase LPIN1 isoform X10

      UniProtKB/TrEMBL
      A6HAS7, Q5XIM8
    11. XM_039112204.2XP_038968132.1  phosphatidate phosphatase LPIN1 isoform X11

      Conserved Domains (2) summary
      pfam08235
      Location:464689
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:276393
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    12. XM_063261886.1XP_063117956.1  phosphatidate phosphatase LPIN1 isoform X9

      UniProtKB/TrEMBL
      A6HAS7

    RNA

    1. XR_010052085.1 RNA Sequence

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