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    Ctss cathepsin S [ Rattus norvegicus (Norway rat) ]

    Gene ID: 50654, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ctssprovided by RGD
    Official Full Name
    cathepsin Sprovided by RGD
    Primary source
    RGD:621513
    See related
    EnsemblRapid:ENSRNOG00000021157 AllianceGenome:RGD:621513
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables cysteine-type peptidase activity. Involved in bone resorption and metanephros development. Located in cell surface. Biomarker of intracranial aneurysm. Human ortholog(s) of this gene implicated in neuropathy. Orthologous to human CTSS (cathepsin S). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 780.2), Brain (RPKM 595.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ctss in Genome Data Viewer
    Location:
    2q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185775316..185803440)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (183086437..183114483)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (197655780..197679768)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 epsilon 1, pseudogene 1 Neighboring gene cathepsin K Neighboring gene ataxin-8-like Neighboring gene HORMA domain containing 1 Neighboring gene transfer RNA leucine (anticodon AAG) 16 Neighboring gene golgi phosphoprotein 3-like Neighboring gene RNA, U6 small nuclear 857

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables collagen binding  
    enables collagen binding  
    enables cysteine-type endopeptidase activity  
    enables cysteine-type endopeptidase activity  
    enables cysteine-type endopeptidase activity  
    enables cysteine-type peptidase activity PubMed 
    enables cysteine-type peptidase activity  
    enables fibronectin binding  
    enables fibronectin binding  
    enables laminin binding  
    enables laminin binding  
    enables peptidase activity  
    enables proteoglycan binding  
    enables proteoglycan binding  
    enables serine-type endopeptidase activity  
    Items 1 - 25 of 27
    Process Evidence Code Pubs
    involved_in adaptive immune response  
    involved_in adaptive immune response  
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II  
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II  
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II  
    involved_in antigen processing and presentation of peptide antigen  
    involved_in apoptotic process  
    involved_in basement membrane disassembly  
    involved_in basement membrane disassembly  
    involved_in bone resorption PubMed 
    involved_in cellular response to thyroid hormone stimulus  
    involved_in cellular response to thyroid hormone stimulus  
    involved_in collagen catabolic process  
    involved_in collagen catabolic process  
    involved_in metanephros development PubMed 
    involved_in positive regulation of cation channel activity  
    acts_upstream_of_or_within positive regulation of inflammatory response  
    involved_in protein processing  
    involved_in protein processing  
    involved_in proteolysis  
    acts_upstream_of_or_within proteolysis  
    involved_in proteolysis  
    involved_in proteolysis involved in protein catabolic process  
    involved_in proteolysis involved in protein catabolic process  
    involved_in proteolysis involved in protein catabolic process  
    involved_in response to acidic pH  
    involved_in response to acidic pH  
    Items 1 - 25 of 27
    Component Evidence Code Pubs
    located_in cell surface PubMed 
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in extracellular space  
    located_in extracellular space  
    located_in intracellular membrane-bounded organelle  
    located_in late endosome  
    located_in late endosome  
    is_active_in lysosome  
    located_in lysosome  
    located_in lysosome  
    located_in membrane  
    located_in phagocytic vesicle  
    located_in phagocytic vesicle  
    located_in phagocytic vesicle  

    General protein information

    Preferred Names
    cathepsin S
    NP_059016.2
    XP_063138486.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017320.2NP_059016.2  cathepsin S preproprotein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6AES4, A6K2Z7
      Related
      ENSRNOP00000092901.1, ENSRNOT00000105420.2
      Conserved Domains (2) summary
      smart00848
      Location:3796
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:124339
      Peptidase_C1; Papain family cysteine protease

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      185775316..185803440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282416.1XP_063138486.1  cathepsin S isoform X1

      UniProtKB/TrEMBL
      A6K2Z7
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