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    Pip4k2a phosphatidylinositol-5-phosphate 4-kinase type 2 alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116723, updated on 9-Dec-2024

    Summary

    Symbol
    Pip4k2aprovided by RGD
    Full Name
    phosphatidylinositol-5-phosphate 4-kinase type 2 alphaprovided by RGD
    Primary source
    RGD:621708
    See related
    EnsemblRapid:ENSRNOG00000016670 AllianceGenome:RGD:621708
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pip5k2a
    Summary
    Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; and protein homodimerization activity. Predicted to be involved in several processes, including 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; autophagosome-lysosome fusion; and megakaryocyte development. Predicted to be located in autophagosome; cytosol; and lysosome. Predicted to be active in plasma membrane. Orthologous to human PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase type 2 alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 240.7), Thymus (RPKM 121.3) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Pip4k2a in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (86405080..86576597, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (81496669..81668180, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (85533056..85748843, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 6 Neighboring gene uncharacterized LOC120097847 Neighboring gene hypothetical LOC100361451 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene armadillo repeat containing 3 Neighboring gene PICALM interacting mitotic regulator like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process  
    involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process  
    involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process  
    involved_in autophagosome-lysosome fusion  
    involved_in autophagosome-lysosome fusion  
    involved_in autophagosome-lysosome fusion  
    involved_in megakaryocyte development  
    involved_in megakaryocyte development  
    involved_in negative regulation of insulin receptor signaling pathway  
    involved_in negative regulation of insulin receptor signaling pathway  
    involved_in negative regulation of insulin receptor signaling pathway  
    involved_in phosphatidylinositol phosphate biosynthetic process  
    involved_in positive regulation of autophagosome assembly  
    involved_in positive regulation of autophagosome assembly  
    involved_in regulation of autophagy  
    involved_in regulation of autophagy  
    involved_in vesicle-mediated cholesterol transport  
    involved_in vesicle-mediated cholesterol transport  
    involved_in vesicle-mediated cholesterol transport  
    Component Evidence Code Pubs
    located_in autophagosome  
    located_in autophagosome  
    located_in cytosol  
    located_in cytosol  
    located_in lysosome  
    located_in lysosome  
    located_in lysosome  
    located_in nucleus  
    located_in photoreceptor inner segment  
    located_in photoreceptor outer segment  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
    Names
    1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha
    1-phosphatidylinositol-5-phosphate 4-kinase A
    PI(5)P 4-kinase type II alpha
    PIP4KII-alpha
    PIPK2 alpha
    diphosphoinositide kinase 2-alpha
    phosphatidylinositol 5-phosphate 4-kinase type II alpha
    phosphatidylinositol-4-phosphate 5-kinase, type II, alpha
    phosphatidylinositol-5-phosphate 4-kinase type-2 alpha-like
    NP_446378.1
    XP_038951232.1
    XP_038951233.1
    XP_038951234.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053926.2NP_446378.1  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

      See identical proteins and their annotated locations for NP_446378.1

      Status: VALIDATED

      Source sequence(s)
      AB032899, BQ782736, CB715008, CO573943, CV077559, DV713604
      UniProtKB/Swiss-Prot
      Q9R0I8
      UniProtKB/TrEMBL
      A6JM97
      Related
      ENSRNOP00000022375.8, ENSRNOT00000022375.9
      Conserved Domains (1) summary
      cd17309
      Location:27403
      PIPKc_PIP5K2A; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP5K2A) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      86405080..86576597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095306.2XP_038951234.1  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X3

      UniProtKB/TrEMBL
      A6JM97
      Conserved Domains (1) summary
      cl28923
      Location:27352
      PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
    2. XM_039095305.2XP_038951233.1  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X2

      Conserved Domains (1) summary
      cl28923
      Location:72361
      PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
    3. XM_039095304.2XP_038951232.1  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1

      UniProtKB/TrEMBL
      A6JM97
      Conserved Domains (1) summary
      cl28923
      Location:27283
      PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
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