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    Cd80 Cd80 molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25408, updated on 9-Dec-2024

    Summary

    Symbol
    Cd80provided by RGD
    Full Name
    Cd80 moleculeprovided by RGD
    Primary source
    RGD:2314
    See related
    EnsemblRapid:ENSRNOG00000001527 AllianceGenome:RGD:2314
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    B7-1
    Summary
    Predicted to enable receptor ligand activity. Involved in positive regulation of T cell proliferation. Located in cell surface. Used to study adult T-cell leukemia/lymphoma; anti-basement membrane glomerulonephritis; high grade glioma; and periodontal disease. Biomarker of kidney failure. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human CD80 (CD80 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 25.4), Thymus (RPKM 23.2) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cd80 in Genome Data Viewer
    Location:
    11q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (75760073..75798978, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (62254543..62293414, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (64815201..64855293, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene protein O-glucosyltransferase 1 Neighboring gene uncharacterized LOC103693581 Neighboring gene translocase of inner mitochondrial membrane domain containing 1 Neighboring gene uncharacterized LOC108352341 Neighboring gene ADP-ribosylarginine hydrolase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables coreceptor activity  
    enables receptor ligand activity  
    Process Evidence Code Pubs
    involved_in T cell activation  
    involved_in T cell costimulation  
    acts_upstream_of_or_within T cell costimulation  
    involved_in cell surface receptor signaling pathway  
    involved_in cellular response to lipopolysaccharide  
    acts_upstream_of_or_within cellular response to lipopolysaccharide  
    involved_in immune response  
    involved_in negative regulation of T cell mediated immunity  
    involved_in negative regulation of T cell proliferation  
    involved_in positive regulation of T cell proliferation  
    involved_in positive regulation of T cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of T cell proliferation  
    acts_upstream_of_or_within positive regulation of alpha-beta T cell proliferation  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    Component Evidence Code Pubs
    located_in cell surface PubMed 
    is_active_in external side of plasma membrane  
    located_in external side of plasma membrane  
    part_of protein complex involved in cell adhesion  

    General protein information

    Preferred Names
    T-lymphocyte activation antigen CD80
    Names
    CD80 antigen
    CD80-like
    Cd80 a rat homolog of the human CD28/CTLA - 4 ligand (B7-1)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418663.2NP_001405592.1  T-lymphocyte activation antigen CD80 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6IR66, O35187
      Related
      ENSRNOP00000002089.6, ENSRNOT00000002089.6
    2. NM_012926.2NP_037058.2  T-lymphocyte activation antigen CD80 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6IR66, O35187
      Conserved Domains (3) summary
      cd00096
      Location:4146
      Ig; Ig strand A [structural motif]
      cd16083
      Location:147237
      IgC1_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:40144
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      75760073..75798978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088035.2XP_038943963.1  T-lymphocyte activation antigen CD80 isoform X1

      UniProtKB/TrEMBL
      G3V671, O35187
      Conserved Domains (3) summary
      cd00096
      Location:4146
      Ig; Ig strand A [structural motif]
      cd16083
      Location:147237
      IgC1_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:40144
      Ig; Immunoglobulin domain
    2. XM_039088036.2XP_038943964.1  T-lymphocyte activation antigen CD80 isoform X1

      UniProtKB/TrEMBL
      G3V671, O35187
      Related
      ENSRNOP00000110921.1, ENSRNOT00000172449.1
      Conserved Domains (3) summary
      cd00096
      Location:4146
      Ig; Ig strand A [structural motif]
      cd16083
      Location:147237
      IgC1_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:40144
      Ig; Immunoglobulin domain
    3. XM_063270308.1XP_063126378.1  T-lymphocyte activation antigen CD80 isoform X2

      UniProtKB/TrEMBL
      A6IR66, O35187
    4. XM_063270307.1XP_063126377.1  T-lymphocyte activation antigen CD80 isoform X1

      UniProtKB/TrEMBL
      G3V671, O35187

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