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    Rbx1 ring-box 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300084, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rbx1provided by RGD
    Official Full Name
    ring-box 1provided by RGD
    Primary source
    RGD:1308453
    See related
    AllianceGenome:RGD:1308453
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including cullin family protein binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including positive regulation of intracellular signal transduction; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein modification by small protein conjugation. Predicted to act upstream of or within protein K48-linked ubiquitination; protein catabolic process; and protein monoubiquitination. Part of VCB complex. Orthologous to human RBX1 (ring-box 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 407.4), Brain (RPKM 387.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rbx1 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (114870893..114881194)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (112976863..113001051)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (122700849..122710907)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37A, pseudogene 2 Neighboring gene transfer RNA proline (anticodon AGG) 43 Neighboring gene uncharacterized LOC120093697 Neighboring gene U6 spliceosomal RNA Neighboring gene E1A binding protein p300

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC116275

    Gene Ontology Provided by RGD

    Items 1 - 25 of 27
    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  
    involved_in T cell activation  
    involved_in cellular response to UV  
    involved_in cellular response to amino acid stimulus  
    involved_in cellular response to oxidative stress  
    involved_in negative regulation of response to oxidative stress  
    involved_in negative regulation of type I interferon production  
    involved_in positive regulation of TORC1 signaling  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of protein autoubiquitination  
    involved_in positive regulation of protein catabolic process  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    acts_upstream_of_or_within protein K48-linked ubiquitination  
    involved_in protein K48-linked ubiquitination  
    acts_upstream_of_or_within protein catabolic process  
    acts_upstream_of_or_within protein monoubiquitination  
    involved_in protein monoubiquitination  
    involved_in protein neddylation  
    involved_in protein polyubiquitination  
    involved_in protein ubiquitination  
    involved_in protein ubiquitination  
    involved_in spermatogenesis  
    involved_in ubiquitin-dependent protein catabolic process  
    involved_in ubiquitin-dependent protein catabolic process  
    involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway  
    Items 1 - 25 of 27
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex  
    part_of Cul3-RING ubiquitin ligase complex  
    part_of Cul4A-RING E3 ubiquitin ligase complex  
    part_of Cul4B-RING E3 ubiquitin ligase complex  
    part_of Cul5-RING ubiquitin ligase complex  
    part_of Cul7-RING ubiquitin ligase complex  
    part_of SCF ubiquitin ligase complex  
    part_of VCB complex PubMed 
    part_of cullin-RING ubiquitin ligase complex  
    part_of cullin-RING ubiquitin ligase complex  
    is_active_in cytoplasm  
    located_in cytosol  
    located_in nucleoplasm  
    is_active_in nucleus  
    is_active_in nucleus  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RBX1
    Names
    RING-box protein 1
    ring-box 1, E3 ubiquitin protein ligase
    NP_001029307.1
    XP_038934770.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034135.2NP_001029307.1  E3 ubiquitin-protein ligase RBX1

      See identical proteins and their annotated locations for NP_001029307.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2JUC8, Q498D8
      Conserved Domains (1) summary
      cd16485
      Location:40101
      mRING-H2-C3H2C2D_RBX1; modified RING finger, H2 subclass (C3H2C2D-type), found in RING-box protein 1 (RBX1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      114870893..114881194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078842.2XP_038934770.1  E3 ubiquitin-protein ligase RBX1 isoform X1

      Conserved Domains (1) summary
      cl17238
      Location:2052
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
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