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    Tppp tubulin polymerization promoting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361466, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tpppprovided by RGD
    Official Full Name
    tubulin polymerization promoting proteinprovided by RGD
    Primary source
    RGD:1310121
    See related
    EnsemblRapid:ENSRNOG00000028261 AllianceGenome:RGD:1310121
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    TPPP/p25; RGD1310121
    Summary
    Predicted to enable several functions, including magnesium ion binding activity; microtubule nucleator activity; and protein homodimerization activity. Involved in myelin assembly and positive regulation of myelination. Located in postsynaptic Golgi apparatus. Orthologous to human TPPP (tubulin polymerization promoting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 426.2), Heart (RPKM 161.1) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Tppp in Genome Data Viewer
    Location:
    1p11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (31085680..31109703, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (29257111..29281134, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (31866755..31890778, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 9 member A3 Neighboring gene centrosomal protein 72 Neighboring gene zinc finger, DHHC-type containing 11 Neighboring gene uncharacterized LOC134484978 Neighboring gene bromodomain containing 9 Neighboring gene thyroid hormone receptor interactor 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    enables magnesium ion binding  
    enables magnesium ion binding  
    enables magnesium ion binding  
    enables membrane scission GTPase motor activity  
    enables microtubule binding  
    enables microtubule nucleator activity  
    enables microtubule nucleator activity  
    enables protein binding PubMed 
    enables protein dimerization activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables tubulin binding  
    enables tubulin binding  
    enables tubulin binding  
    enables tubulin binding  
    Items 1 - 25 of 37
    Process Evidence Code Pubs
    involved_in astral microtubule organization  
    involved_in astral microtubule organization  
    involved_in astral microtubule organization  
    involved_in cell division  
    involved_in microtubule bundle formation  
    involved_in microtubule bundle formation  
    involved_in microtubule bundle formation  
    involved_in microtubule bundle formation  
    involved_in microtubule nucleation by microtubule organizing center  
    involved_in microtubule nucleation by microtubule organizing center  
    involved_in microtubule nucleation by microtubule organizing center  
    involved_in microtubule polymerization  
    involved_in microtubule polymerization  
    involved_in microtubule polymerization  
    involved_in microtubule polymerization  
    involved_in myelin assembly  
    involved_in myelin assembly PubMed 
    involved_in myelin assembly  
    involved_in negative regulation of tubulin deacetylation  
    involved_in negative regulation of tubulin deacetylation  
    involved_in negative regulation of tubulin deacetylation  
    involved_in oligodendrocyte development  
    involved_in oligodendrocyte development  
    involved_in oligodendrocyte development  
    involved_in oligodendrocyte differentiation  
    involved_in oligodendrocyte differentiation  
    involved_in positive regulation of myelination  
    involved_in positive regulation of myelination PubMed 
    involved_in positive regulation of myelination  
    involved_in positive regulation of protein polymerization  
    involved_in positive regulation of protein polymerization  
    involved_in positive regulation of protein polymerization  
    involved_in positive regulation of protein polymerization  
    involved_in positive regulation of protein-containing complex assembly  
    involved_in regulation of microtubule cytoskeleton organization  
    involved_in regulation of microtubule cytoskeleton organization  
    involved_in regulation of microtubule cytoskeleton organization  
    Items 1 - 25 of 37
    Items 1 - 20 of 22
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    is_active_in Golgi apparatus  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    colocalizes_with microtubule  
    located_in microtubule  
    located_in microtubule  
    located_in microtubule bundle  
    located_in microtubule bundle  
    located_in microtubule organizing center  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in mitotic spindle  
    located_in mitotic spindle  
    located_in mitotic spindle  
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in postsynaptic Golgi apparatus PubMed 
    Items 1 - 20 of 22

    General protein information

    Preferred Names
    tubulin polymerization-promoting protein
    Names
    25 kDa brain-specific protein
    p25-alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108461.1NP_001101931.1  tubulin polymerization-promoting protein

      See identical proteins and their annotated locations for NP_001101931.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474002
      UniProtKB/Swiss-Prot
      A0A0G2K2D6, D3ZQL7
      UniProtKB/TrEMBL
      A0A5H1ZRV3, A0A8I6A1G2
      Related
      ENSRNOP00000085473.2, ENSRNOT00000115773.2
      Conserved Domains (1) summary
      pfam05517
      Location:51206
      p25-alpha

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      31085680..31109703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006227794.4XP_006227856.1  tubulin polymerization-promoting protein isoform X1

      See identical proteins and their annotated locations for XP_006227856.1

      UniProtKB/Swiss-Prot
      A0A0G2K2D6, D3ZQL7
      UniProtKB/TrEMBL
      A0A5H1ZRV3, A0A8I6A1G2
      Conserved Domains (1) summary
      pfam05517
      Location:51206
      p25-alpha
    2. XM_006227793.4XP_006227855.1  tubulin polymerization-promoting protein isoform X1

      See identical proteins and their annotated locations for XP_006227855.1

      UniProtKB/Swiss-Prot
      A0A0G2K2D6, D3ZQL7
      UniProtKB/TrEMBL
      A0A5H1ZRV3, A0A8I6A1G2
      Conserved Domains (1) summary
      pfam05517
      Location:51206
      p25-alpha
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