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    Adcy2 adenylate cyclase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81636, updated on 27-Dec-2024

    Summary

    Official Symbol
    Adcy2provided by RGD
    Official Full Name
    adenylate cyclase 2provided by RGD
    Primary source
    RGD:619965
    See related
    EnsemblRapid:ENSRNOG00000032150 AllianceGenome:RGD:619965
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AC2
    Summary
    Enables several functions, including G-protein beta/gamma-subunit complex binding activity; adenylate cyclase binding activity; and metal ion binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; and cellular response to forskolin. Located in membrane raft and plasma membrane. Part of protein-containing complex. Orthologous to human ADCY2 (adenylate cyclase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 209.9), Muscle (RPKM 172.5) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Adcy2 in Genome Data Viewer
    Location:
    1p11
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (36204054..36650645)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (34375639..34822252)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (37043071..37698390)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 2 subunit beta 1, pseudogene 1 Neighboring gene proteasome 20S subunit alpha 7, pseudogene 1 Neighboring gene transfer RNA proline (anticodon AGG) 24 Neighboring gene proteasome activator complex subunit 2-like Neighboring gene RNA, U6 small nuclear 783 Neighboring gene cilia and flagella associated protein 90 Neighboring gene FAST kinase domains 3 Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase reductase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G-protein beta/gamma-subunit complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables adenylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables adenylate cyclase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables adenylate cyclase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    adenylate cyclase type 2
    Names
    ATP pyrophosphate-lyase 2
    adenylate cyclase 2 (brain)
    adenylate cyclase type II
    adenylyl cyclase 2
    NP_112269.2
    XP_038947960.1
    XP_038947965.1
    XP_038947966.1
    XP_038947972.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031007.3NP_112269.2  adenylate cyclase type 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P26769
      UniProtKB/TrEMBL
      A6JV23, F1LV12
      Related
      ENSRNOP00000038994.3, ENSRNOT00000047627.5
      Conserved Domains (3) summary
      pfam00211
      Location:8821081
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:37264
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:499603
      DUF1053; Domain of Unknown Function (DUF1053)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      36204054..36650645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092044.2XP_038947972.1  adenylate cyclase type 2 isoform X4

      Conserved Domains (3) summary
      pfam00211
      Location:285469
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:37264
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:499603
      DUF1053; Domain of Unknown Function (DUF1053)
    2. XM_039092038.2XP_038947966.1  adenylate cyclase type 2 isoform X3

      Conserved Domains (3) summary
      pfam00211
      Location:285469
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:37264
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:499603
      DUF1053; Domain of Unknown Function (DUF1053)
    3. XM_039092032.2XP_038947960.1  adenylate cyclase type 2 isoform X1

      UniProtKB/Swiss-Prot
      P26769
      Conserved Domains (3) summary
      pfam00211
      Location:8361035
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:37264
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:499603
      DUF1053; Domain of Unknown Function (DUF1053)
    4. XM_039092037.2XP_038947965.1  adenylate cyclase type 2 isoform X2

      UniProtKB/Swiss-Prot
      P26769
      Related
      ENSRNOP00000109970.1, ENSRNOT00000127647.1
      Conserved Domains (3) summary
      pfam00211
      Location:8161015
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:61198
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:433537
      DUF1053; Domain of Unknown Function (DUF1053)