Arrb2 arrestin, beta 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arrb2provided by RGD
Official Full Name: arrestin, beta 2provided by RGD
Primary source: RGD:2157
See related: EnsemblRapid:ENSRNOG00000019308 AllianceGenome:RGD:2157
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BARRES
Summary: Enables several functions, including 14-3-3 protein binding activity; G protein-coupled receptor binding activity; and arrestin family protein binding activity. Involved in several processes, including regulation of apoptotic process; regulation of protein modification process; and regulation of signal transduction. Located in several cellular components, including basolateral plasma membrane; dendritic spine; and postsynaptic membrane. Is active in glutamatergic synapse and postsynaptic density. Biomarker of several diseases, including alcohol dependence; brain infarction; drug psychosis; liver disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in glioblastoma; heroin dependence; nicotine dependence; and opiate dependence. Orthologous to human ARRB2 (arrestin beta 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 253.6), Spleen (RPKM 193.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (55645539..55653485)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (55146887..55154854)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (57040252..57048045)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crystal Structure of beta-Arrestin 2 in Complex with CXCR7 Phosphopeptide.
Title: Crystal Structure of β-Arrestin 2 in Complex with CXCR7 Phosphopeptide.
Negative relationship between brain alpha1A-AR neurotransmission and betaArr2 levels in anxious adolescent rats subjected to early life stress.
Title: Negative relationship between brain α(1A)-AR neurotransmission and βArr2 levels in anxious adolescent rats subjected to early life stress.
Repeated social defeat promotes persistent inflammatory changes in splenic myeloid cells; decreased expression of beta-arrestin-2 (ARRB2) and increased expression of interleukin-6 (IL-6).
Title: Repeated social defeat promotes persistent inflammatory changes in splenic myeloid cells; decreased expression of β-arrestin-2 (ARRB2) and increased expression of interleukin-6 (IL-6).
Conformational Dynamics and Functional Implications of Phosphorylated beta-Arrestins.
Title: Conformational Dynamics and Functional Implications of Phosphorylated β-Arrestins.
beta-arrestin-2 enhances intestinal epithelial apoptosis in necrotizing enterocolitis.
Title: β-arrestin-2 enhances intestinal epithelial apoptosis in necrotizing enterocolitis.
Knockdown of beta-arrestin1 or 2 in the post-MI cardiac fibroblasts (CF) inhibited transformation to myofibroblasts as well as basal and TGF-beta-stimulated collagen synthesis. These data suggest that beta-arrestins can regulate CF biology.
Title: Regulation of cardiac fibroblast-mediated maladaptive ventricular remodeling by β-arrestins.
This study demonstrated that arrestin2 functions as a key regulator in the sympathetic-triggered immunodepression after stroke.
Title: β-arrestin2 functions as a key regulator in the sympathetic-triggered immunodepression after stroke.
Results showed that sexual experience acquisition improved male's copulatory ability and induced persistent changes in the density, cellular distribution and activation of MOR and beta-arrestin2 in Ventral Tegmental Area neurons. DOR density was not modified, but its cellular location changed after sexual experience.
Title: Opioid receptor and β-arrestin2 densities and distribution change after sexual experience in the ventral tegmental area of male rats.
results indicate that Wnt5a-mediated JNK3 activation participates in Ischemia/Reperfusion brain injury by targeting the Dvl-1-beta-arrestin2/JNK3 interaction
Title: Targeting the Dvl-1/β-arrestin2/JNK3 interaction disrupts Wnt5a-JNK3 signaling and protects hippocampal CA1 neurons during cerebral ischemia reperfusion.
Arrb2 induces cardiomyocyte death by interacting with the p85 subunit of PI3K, and negatively regulating the formation of p85-PI3K/CaV3 survival complex, thus blocking activation of PI3K-Akt-GSK3beta cell survival signalling pathway in cardiac ischemia-reperfusion.
Title: β-arrestin 2 mediates cardiac ischemia-reperfusion injury via inhibiting GPCR-independent cell survival signalling.

Submit: New GeneRIF Correction See all GeneRIFs (57)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables D1 dopamine receptor binding	IEA Inferred from Electronic Annotation more info
enables D1 dopamine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables D1 dopamine receptor binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables alpha-1A adrenergic receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables alpha-1B adrenergic receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables angiotensin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables angiotensin receptor binding	IEA Inferred from Electronic Annotation more info
enables angiotensin receptor binding	ISO Inferred from Sequence Orthology more info
enables arrestin family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables follicle-stimulating hormone receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables mitogen-activated protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables platelet activating factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase B binding	IEA Inferred from Electronic Annotation more info
enables protein kinase B binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables type 1 angiotensin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables type 2A serotonin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables type 2A serotonin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adult walking behavior	IEA Inferred from Electronic Annotation more info
involved_in adult walking behavior	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in desensitization of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in detection of temperature stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in follicle-stimulating hormone signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-12 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of natural killer cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of opioid receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of release of cytochrome c from mitochondria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of opioid receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, dopaminergic	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic transmission, dopaminergic	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic signal transduction	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic signal transduction	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in response to morphine	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in endocytic vesicle	IEA Inferred from Electronic Annotation more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: beta-arrestin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012911.3 → NP_037043.1 beta-arrestin-2

See identical proteins and their annotated locations for NP_037043.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P29067

UniProtKB/TrEMBL

A0A8L2QE39, A6HG47

Related

ENSRNOP00000103308.1, ENSRNOT00000162402.1

Conserved Domains (2) summary

smart01017
Location:199 → 350

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:19 → 175

Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RNA

NR_190853.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010
NR_190854.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

55645539..55653485

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268460.1 → XP_063124530.1 beta-arrestin-2 isoform X3

UniProtKB/TrEMBL

A0A8L2QE39
XM_063268463.1 → XP_063124533.1 beta-arrestin-2 isoform X5

UniProtKB/TrEMBL

A0A8L2QE39

Related

ENSRNOP00000026207.8, ENSRNOT00000026207.9
XM_063268459.1 → XP_063124529.1 beta-arrestin-2 isoform X2

UniProtKB/TrEMBL

A0A8L2QE39

Related

ENSRNOP00000102697.1, ENSRNOT00000133479.1
XM_063268461.1 → XP_063124531.1 beta-arrestin-2 isoform X3

UniProtKB/TrEMBL

A0A8L2QE39
XM_063268464.1 → XP_063124534.1 beta-arrestin-2 isoform X6
XM_039085269.2 → XP_038941197.1 beta-arrestin-2 isoform X4

Conserved Domains (2) summary

smart01017
Location:109 → 260

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

cl22903
Location:6 → 85

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
XM_039085267.2 → XP_038941195.1 beta-arrestin-2 isoform X1

UniProtKB/TrEMBL

A0A8L2QE39

Related

ENSRNOP00000095625.2, ENSRNOT00000108666.2

Conserved Domains (2) summary

smart01017
Location:198 → 349

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

cl22903
Location:18 → 174

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
XM_063268462.1 → XP_063124532.1 beta-arrestin-2 isoform X4

Related

ENSRNOP00000103352.1, ENSRNOT00000171242.1