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    Flywch1 FLYWCH-type zinc finger 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360488, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Flywch1provided by RGD
    Official Full Name
    FLYWCH-type zinc finger 1provided by RGD
    Primary source
    RGD:1309385
    See related
    EnsemblRapid:ENSRNOG00000004333 AllianceGenome:RGD:1309385
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309385
    Summary
    Predicted to enable transcription coactivator binding activity and transcription corepressor activity. Predicted to be involved in DNA damage response and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nuclear body; and pericentric heterochromatin. Predicted to be part of transcription regulator complex. Orthologous to human FLYWCH1 (FLYWCH-type zinc finger 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 175.5), Adrenal (RPKM 87.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Flywch1 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (13279232..13298955, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (12774644..12794373, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (13087925..13107833, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9530082P21 gene like Neighboring gene kringle containing transmembrane protein 2 Neighboring gene FLYWCH family member 2 Neighboring gene uncharacterized LOC134480759 Neighboring gene serine/arginine repetitive matrix 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in pericentric heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    FLYWCH-type zinc finger-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398792.1 → NP_001385721.1  FLYWCH-type zinc finger-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A1L1L4, F7FDF2
      Related
      ENSRNOP00000005879.7, ENSRNOT00000005879.9
      Conserved Domains (3) summary
      pfam04500
      Location:231 → 289
      FLYWCH; FLYWCH zinc finger domain
      pfam15423
      Location:1 → 83
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
      pfam16662
      Location:290 → 357
      FLYWCH_u; FLYWCH-type zinc finger-containing protein 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      13279232..13298955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087076.2 → XP_038943004.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A1L1L4, F7FDF2
      Conserved Domains (3) summary
      pfam04500
      Location:231 → 289
      FLYWCH; FLYWCH zinc finger domain
      pfam15423
      Location:1 → 83
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
      pfam16662
      Location:290 → 357
      FLYWCH_u; FLYWCH-type zinc finger-containing protein 1

    2. XM_063269302.1 → XP_063125372.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A1L1L4, F7FDF2

    3. XM_063269305.1 → XP_063125375.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A1L1L4, F7FDF2

    4. XM_006245882.4 → XP_006245944.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006245944.1

      UniProtKB/TrEMBL
      A1L1L4, F7FDF2
      Conserved Domains (3) summary
      pfam04500
      Location:231 → 289
      FLYWCH; FLYWCH zinc finger domain
      pfam15423
      Location:1 → 83
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
      pfam16662
      Location:290 → 357
      FLYWCH_u; FLYWCH-type zinc finger-containing protein 1

    5. XM_063269301.1 → XP_063125371.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A1L1L4, F7FDF2

    6. XM_063269303.1 → XP_063125373.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A1L1L4, F7FDF2

    7. XM_063269299.1 → XP_063125369.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A1L1L4, F7FDF2

    8. XM_063269300.1 → XP_063125370.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A1L1L4, F7FDF2

    9. XM_063269304.1 → XP_063125374.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A1L1L4, F7FDF2
    Nucleotide Protein Strain
    Heading Accession and Version

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