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    Crebl2 cAMP responsive element binding protein-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362453, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Crebl2provided by RGD
    Official Full Name
    cAMP responsive element binding protein-like 2provided by RGD
    Primary source
    RGD:1309502
    See related
    EnsemblRapid:ENSRNOG00000067300 AllianceGenome:RGD:1309502
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity and DNA-binding transcription factor activity. Predicted to be involved in several processes, including positive regulation of D-glucose import; positive regulation of macromolecule metabolic process; and protein stabilization. Predicted to be active in nucleus. Orthologous to human CREBL2 (cAMP responsive element binding protein like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 118.7), Kidney (RPKM 116.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Crebl2 in Genome Data Viewer
    Location:
    4q43
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (169404630..169430618)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (167673359..167699299)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (168599387..168625239)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene MANSC domain containing 1 Neighboring gene BLOC-1 related complex subunit 5 Neighboring gene dual specificity phosphatase 16 Neighboring gene uncharacterized LOC108350781 Neighboring gene G protein-coupled receptor 19 Neighboring gene cyclin-dependent kinase inhibitor 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipocytes. Ma X, et al. Biochem J, 2011 Oct 1. PMID 21728997
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109304

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of D-glucose import ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of D-glucose import ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cAMP-responsive element-binding protein-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015027.1 → NP_001015027.1  cAMP-responsive element-binding protein-like 2

      See identical proteins and their annotated locations for NP_001015027.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091323
      UniProtKB/Swiss-Prot
      Q5BJU6
      UniProtKB/TrEMBL
      A6IME0
      Conserved Domains (1) summary
      cd14709
      Location:25 → 80
      bZIP_CREBL2; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein-like 2 (CREBL2): a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      169404630..169430618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107908.2 → XP_038963836.1  cAMP-responsive element-binding protein-like 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ANJ8, A6IMD9
      Related
      ENSRNOP00000097590.1, ENSRNOT00000103810.2
      Conserved Domains (1) summary
      cd14709
      Location:25 → 71
      bZIP_CREBL2; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein-like 2 (CREBL2): a DNA-binding and dimerization domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BJU6.1 GenPept UniProtKB/Swiss-Prot:Q5BJU6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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