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    Spout1 SPOUT domain containing methyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499770, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spout1provided by RGD
    Official Full Name
    SPOUT domain containing methyltransferase 1provided by RGD
    Primary source
    RGD:1563514
    See related
    EnsemblRapid:ENSRNOG00000025711 AllianceGenome:RGD:1563514
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable miRNA binding activity. Predicted to be involved in maintenance of centrosome location and miRNA processing. Predicted to act upstream of with a positive effect on post-transcriptional regulation of gene expression. Predicted to be active in kinetochore; mitotic spindle; and spindle pole centrosome. Orthologous to human SPOUT1 (SPOUT domain containing methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 98.2), Heart (RPKM 81.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spout1 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (33849007..33856564, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (13451191..13458918, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (8743890..8751634, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene zyg-11 related, cell cycle regulator Neighboring gene TBC1 domain family, member 13 Neighboring gene endonuclease G Neighboring gene kynurenine aminotransferase 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly. Ohta S, et al. Mol Biol Cell, 2015 Apr 1. PMID 25657325, Free PMC Article
    2. A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. Treiber T, et al. Mol Cell, 2017 Apr 20. PMID 28431233
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112863

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables miRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in maintenance of centrosome location IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of centrosome location ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect post-transcriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle pole centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    putative methyltransferase C9orf114 homolog
    Names
    uncharacterized protein C9orf114 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398931.1 → NP_001385860.1  putative methyltransferase C9orf114 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2QC59, A6JTV8
      Related
      ENSRNOP00000036781.6, ENSRNOT00000030623.8
      Conserved Domains (1) summary
      pfam02598
      Location:76 → 365
      Methyltrn_RNA_3; Putative RNA methyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      33849007..33856564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284347.1 → XP_063140417.1  putative methyltransferase C9orf114 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVR0

    2. XM_006233842.4 → XP_006233904.1  putative methyltransferase C9orf114 homolog isoform X2

      See identical proteins and their annotated locations for XP_006233904.1

      Conserved Domains (1) summary
      pfam02598
      Location:36 → 325
      Methyltrn_RNA_3; Putative RNA methyltransferase

    3. XM_063284348.1 → XP_063140418.1  putative methyltransferase C9orf114 homolog isoform X2

    4. XM_063284346.1 → XP_063140416.1  putative methyltransferase C9orf114 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVR0
      Related
      ENSRNOP00000082855.1, ENSRNOT00000108309.2

    5. XM_063284349.1 → XP_063140419.1  putative methyltransferase C9orf114 homolog isoform X3

      UniProtKB/TrEMBL
      E9PTL4, Q4KM43

    RNA

    1. XR_010064683.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001047110.1: Suppressed sequence

      Description
      NM_001047110.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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