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    Usp6nl USP6 N-terminal like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291309, updated on 9-Dec-2024

    Summary

    Official Symbol
    Usp6nlprovided by RGD
    Official Full Name
    USP6 N-terminal likeprovided by RGD
    Primary source
    RGD:1311786
    See related
    EnsemblRapid:ENSRNOG00000017644 AllianceGenome:RGD:1311786
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in several processes, including plasma membrane to endosome transport; positive regulation of GTPase activity; and retrograde transport, plasma membrane to Golgi. Predicted to be located in plasma membrane. Predicted to be active in cytoplasmic vesicle. Orthologous to human USP6NL (USP6 N-terminal like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 82.8), Spleen (RPKM 71.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Usp6nl in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (76737870..76865953, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (71828433..71956878, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (75759428..75887108, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482604 Neighboring gene uncharacterized LOC134482603 Neighboring gene uncharacterized LOC134482605 Neighboring gene U6 spliceosomal RNA Neighboring gene small EDRK-rich factor 2 pseudogene Neighboring gene uncharacterized LOC134482606

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity  
    enables GTPase activator activity  
    enables small GTPase binding  
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle  
    located_in cytoplasmic vesicle  
    located_in plasma membrane  

    General protein information

    Preferred Names
    USP6 N-terminal-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106120.1NP_001099590.1  USP6 N-terminal-like protein

      See identical proteins and their annotated locations for NP_001099590.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473990
      UniProtKB/TrEMBL
      A0A8I6GLZ6, A6JLX0, D3ZL57
      Related
      ENSRNOP00000046740.2, ENSRNOT00000046266.4
      Conserved Domains (1) summary
      smart00164
      Location:97312
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      76737870..76865953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254233.4XP_006254295.1  USP6 N-terminal-like protein isoform X2

      See identical proteins and their annotated locations for XP_006254295.1

      UniProtKB/TrEMBL
      A0A8I6GLZ6, A6JLX0, D3ZL57
      Conserved Domains (1) summary
      smart00164
      Location:97312
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    2. XM_006254232.5XP_006254294.1  USP6 N-terminal-like protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6A486, A0A8I6GLZ6
      Related
      ENSRNOP00000085611.1, ENSRNOT00000105956.2
      Conserved Domains (1) summary
      smart00164
      Location:114329
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    3. XM_063276241.1XP_063132311.1  USP6 N-terminal-like protein isoform X4

      UniProtKB/TrEMBL
      A0A8I6GLZ6
    4. XM_006254236.5XP_006254298.1  USP6 N-terminal-like protein isoform X4

      UniProtKB/TrEMBL
      A0A8I6GLZ6
      Conserved Domains (2) summary
      smart00164
      Location:18233
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      PHA03307
      Location:287642
      PHA03307; transcriptional regulator ICP4; Provisional
    5. XM_039095538.2XP_038951466.1  USP6 N-terminal-like protein isoform X3

      UniProtKB/TrEMBL
      A0A8I6GH29, A0A8I6GLZ6
      Related
      ENSRNOP00000096234.2, ENSRNOT00000103406.2
      Conserved Domains (2) summary
      smart00164
      Location:41256
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      PHA03307
      Location:310665
      PHA03307; transcriptional regulator ICP4; Provisional
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