Gpld1 glycosylphosphatidylinositol specific phospholipase D1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpld1provided by RGD
Official Full Name: glycosylphosphatidylinositol specific phospholipase D1provided by RGD
Primary source: RGD:631371
See related: EnsemblRapid:ENSRNOG00000017702 AllianceGenome:RGD:631371
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables glycosylphosphatidylinositol phospholipase D activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; glycerophospholipid metabolic process; and regulation of triglyceride metabolic process. Located in extracellular space. Orthologous to human GPLD1 (glycosylphosphatidylinositol specific phospholipase D1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 282.0), Brain (RPKM 65.8) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p11

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (40512659..40560483, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (40084427..40132035, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (42085027..42131344, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPI-PLD directly regulates intracellular diacylglycerol content in rat primary hepatocytes.
Title: Impact of glycosylphosphatidylinositol-specific phospholipase D on hepatic diacylglycerol accumulation, steatosis, and insulin resistance in diet-induced obesity.

Submit: New GeneRIF Correction

General gene information

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Markers

RH131036 (e-PCR)
- UniSTS:214319

BI275110 (e-PCR)
- UniSTS:249560

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glycosylphosphatidylinositol phospholipase D activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycosylphosphatidylinositol phospholipase D activity	IDA Inferred from Direct Assay more info	PubMed
enables glycosylphosphatidylinositol phospholipase D activity	IEA Inferred from Electronic Annotation more info
enables glycosylphosphatidylinositol phospholipase D activity	ISO Inferred from Sequence Orthology more info
enables glycosylphosphatidylinositol phospholipase D activity	TAS Traceable Author Statement more info	PubMed
enables phospholipase D activity	ISO Inferred from Sequence Orthology more info
enables sodium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables sodium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell migration involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell migration involved in sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cholesterol	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cholesterol	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cholesterol	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to pH	IEA Inferred from Electronic Annotation more info
involved_in cellular response to pH	ISO Inferred from Sequence Orthology more info
involved_in cellular response to pH	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to triglyceride	IEA Inferred from Electronic Annotation more info
involved_in cellular response to triglyceride	ISO Inferred from Sequence Orthology more info
involved_in cellular response to triglyceride	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in complement receptor mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in complement receptor mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in complement receptor mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of triglyceride catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in ossification	ISO Inferred from Sequence Orthology more info
involved_in ossification	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylcholine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of alkaline phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glucose metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of high-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of high-density lipoprotein particle clearance	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane protein ectodomain proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein secretion	ISO Inferred from Sequence Orthology more info
involved_in protein secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to glucose	IEA Inferred from Electronic Annotation more info
involved_in response to glucose	ISO Inferred from Sequence Orthology more info
involved_in response to glucose	ISS Inferred from Sequence or Structural Similarity more info
involved_in transepithelial transport	ISO Inferred from Sequence Orthology more info
involved_in transepithelial transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: phosphatidylinositol-glycan-specific phospholipase D

Names: GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipase D; glycosyl-phosphatidylinositol-specific phospholipase D; glycosylphosphatidylinositol phospholipase D

NP_001093982.1

EC 3.1.4.50

XP_006253988.1

EC 3.1.4.50

XP_008769853.1

EC 3.1.4.50

XP_008769857.1

EC 3.1.4.50

XP_017455970.1

EC 3.1.4.50

XP_017455972.1

EC 3.1.4.50

XP_017455973.1

EC 3.1.4.50

XP_038951441.1

EC 3.1.4.50

XP_038951442.1

EC 3.1.4.50

XP_063132255.1

EC 3.1.4.50

XP_063132256.1

EC 3.1.4.50

XP_063132257.1

EC 3.1.4.50

XP_063132258.1

EC 3.1.4.50

XP_063132259.1

EC 3.1.4.50

XP_063132260.1

EC 3.1.4.50

XP_063132261.1

EC 3.1.4.50

XP_063132262.1

EC 3.1.4.50

XP_063132263.1

EC 3.1.4.50

XP_063132264.1

EC 3.1.4.50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100512.1 → NP_001093982.1 phosphatidylinositol-glycan-specific phospholipase D precursor

See identical proteins and their annotated locations for NP_001093982.1

Status: VALIDATED

Source sequence(s)

AJ308109, CO393645, CO571457, CO571976

UniProtKB/Swiss-Prot

Q8R2H5

UniProtKB/TrEMBL

A6KLE5, G3V8B1

Related

ENSRNOP00000024196.2, ENSRNOT00000024196.5

Conserved Domains (3) summary

smart00191
Location:378 → 435

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00882
Location:28 → 220

Zn_dep_PLPC; Zinc dependent phospholipase C

pfam01839
Location:515 → 548

FG-GAP; FG-GAP repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

40512659..40560483 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063276188.1 → XP_063132258.1 phosphatidylinositol-glycan-specific phospholipase D isoform X1

UniProtKB/Swiss-Prot

Q8R2H5

UniProtKB/TrEMBL

A6KLE5, G3V8B1
XM_063276191.1 → XP_063132261.1 phosphatidylinositol-glycan-specific phospholipase D isoform X2

UniProtKB/Swiss-Prot

Q8R2H5
XM_063276187.1 → XP_063132257.1 phosphatidylinositol-glycan-specific phospholipase D isoform X1

UniProtKB/Swiss-Prot

Q8R2H5

UniProtKB/TrEMBL

A6KLE5, G3V8B1
XM_063276193.1 → XP_063132263.1 phosphatidylinositol-glycan-specific phospholipase D isoform X2

UniProtKB/Swiss-Prot

Q8R2H5
XM_039095514.2 → XP_038951442.1 phosphatidylinositol-glycan-specific phospholipase D isoform X1

UniProtKB/Swiss-Prot

Q8R2H5

UniProtKB/TrEMBL

A6KLE5, G3V8B1

Conserved Domains (3) summary

smart00191
Location:378 → 435

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00882
Location:28 → 220

Zn_dep_PLPC; Zinc dependent phospholipase C

pfam01839
Location:515 → 548

FG-GAP; FG-GAP repeat
XM_039095513.2 → XP_038951441.1 phosphatidylinositol-glycan-specific phospholipase D isoform X1

UniProtKB/Swiss-Prot

Q8R2H5

UniProtKB/TrEMBL

A6KLE5, G3V8B1

Conserved Domains (3) summary

smart00191
Location:378 → 435

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00882
Location:28 → 220

Zn_dep_PLPC; Zinc dependent phospholipase C

pfam01839
Location:515 → 548

FG-GAP; FG-GAP repeat
XM_063276185.1 → XP_063132255.1 phosphatidylinositol-glycan-specific phospholipase D isoform X1

UniProtKB/Swiss-Prot

Q8R2H5

UniProtKB/TrEMBL

A6KLE5, G3V8B1
XM_017600484.3 → XP_017455973.1 phosphatidylinositol-glycan-specific phospholipase D isoform X1

UniProtKB/Swiss-Prot

Q8R2H5

UniProtKB/TrEMBL

A6KLE5, G3V8B1

Conserved Domains (3) summary

smart00191
Location:378 → 435

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00882
Location:28 → 220

Zn_dep_PLPC; Zinc dependent phospholipase C

pfam01839
Location:515 → 548

FG-GAP; FG-GAP repeat
XM_063276189.1 → XP_063132259.1 phosphatidylinositol-glycan-specific phospholipase D isoform X2

UniProtKB/Swiss-Prot

Q8R2H5
XM_017600483.3 → XP_017455972.1 phosphatidylinositol-glycan-specific phospholipase D isoform X1

UniProtKB/Swiss-Prot

Q8R2H5

UniProtKB/TrEMBL

A6KLE5, G3V8B1

Conserved Domains (3) summary

smart00191
Location:378 → 435

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00882
Location:28 → 220

Zn_dep_PLPC; Zinc dependent phospholipase C

pfam01839
Location:515 → 548

FG-GAP; FG-GAP repeat
XM_017600481.3 → XP_017455970.1 phosphatidylinositol-glycan-specific phospholipase D isoform X1

UniProtKB/Swiss-Prot

Q8R2H5

UniProtKB/TrEMBL

A6KLE5, G3V8B1

Conserved Domains (3) summary

smart00191
Location:378 → 435

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00882
Location:28 → 220

Zn_dep_PLPC; Zinc dependent phospholipase C

pfam01839
Location:515 → 548

FG-GAP; FG-GAP repeat
XM_063276192.1 → XP_063132262.1 phosphatidylinositol-glycan-specific phospholipase D isoform X2

UniProtKB/Swiss-Prot

Q8R2H5
XM_008771631.4 → XP_008769853.1 phosphatidylinositol-glycan-specific phospholipase D isoform X1

See identical proteins and their annotated locations for XP_008769853.1

UniProtKB/Swiss-Prot

Q8R2H5

UniProtKB/TrEMBL

A6KLE5, G3V8B1

Conserved Domains (3) summary

smart00191
Location:378 → 435

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00882
Location:28 → 220

Zn_dep_PLPC; Zinc dependent phospholipase C

pfam01839
Location:515 → 548

FG-GAP; FG-GAP repeat
XM_008771635.4 → XP_008769857.1 phosphatidylinositol-glycan-specific phospholipase D isoform X2

UniProtKB/Swiss-Prot

Q8R2H5

Conserved Domains (3) summary

smart00191
Location:377 → 434

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00882
Location:28 → 168

Zn_dep_PLPC; Zinc dependent phospholipase C

pfam01839
Location:514 → 547

FG-GAP; FG-GAP repeat
XM_063276190.1 → XP_063132260.1 phosphatidylinositol-glycan-specific phospholipase D isoform X2

UniProtKB/Swiss-Prot

Q8R2H5
XM_063276186.1 → XP_063132256.1 phosphatidylinositol-glycan-specific phospholipase D isoform X1

UniProtKB/Swiss-Prot

Q8R2H5

UniProtKB/TrEMBL

A6KLE5, G3V8B1
XM_063276194.1 → XP_063132264.1 phosphatidylinositol-glycan-specific phospholipase D isoform X4
XM_006253926.4 → XP_006253988.1 phosphatidylinositol-glycan-specific phospholipase D isoform X3

Conserved Domains (2) summary

smart00191
Location:286 → 343

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam01839
Location:423 → 456

FG-GAP; FG-GAP repeat