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    Lgi3 leucine-rich repeat LGI family, member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306013, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lgi3provided by RGD
    Official Full Name
    leucine-rich repeat LGI family, member 3provided by RGD
    Primary source
    RGD:1311079
    See related
    EnsemblRapid:ENSRNOG00000011323 AllianceGenome:RGD:1311079
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in regulation of exocytosis. Predicted to be located in extracellular space and juxtaparanode region of axon. Predicted to be active in synaptic vesicle. Orthologous to human LGI3 (leucine rich repeat LGI family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 328.7), Brain (RPKM 201.9) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lgi3 in Genome Data Viewer
    Location:
    15p11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (52015317..52022445)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (45605611..45612739)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (52220578..52227706)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene bone morphogenetic protein 1 Neighboring gene uncharacterized LOC134482143 Neighboring gene surfactant protein C Neighboring gene uncharacterized LOC134482145 Neighboring gene receptor accessory protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Abeta upregulates and colocalizes with LGI3 in cultured rat astrocytes. Kimura N, et al. Cell Mol Neurobiol, 2007 May. PMID 17387609
    2. Leucine-rich glioma inactivated 3 associates with syntaxin 1. Park WJ, et al. Neurosci Lett, 2008 Oct 31. PMID 18760330
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Activated LGI3 may be involved in the astroglial response against Amyloid beta.
      Title: Abeta upregulates and colocalizes with LGI3 in cultured rat astrocytes.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in juxtaparanode region of axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat LGI family member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107277.1 → NP_001100747.1  leucine-rich repeat LGI family member 3 precursor

      See identical proteins and their annotated locations for NP_001100747.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473951
      UniProtKB/TrEMBL
      A6HTL0, A6HTL1, D3ZN61
      Related
      ENSRNOP00000015104.4, ENSRNOT00000015104.7
      Conserved Domains (6) summary
      smart00370
      Location:135 → 158
      LRR; Leucine-rich repeats, outliers
      sd00031
      Location:68 → 89
      LRR_1; leucine-rich repeat [structural motif]
      pfam03736
      Location:222 → 263
      EPTP; EPTP domain
      pfam12799
      Location:113 → 152
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:112 → 172
      LRR_8; Leucine rich repeat
      cl15307
      Location:170 → 218
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      52015317..52022445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093351.1 → XP_038949279.1  leucine-rich repeat LGI family member 3 isoform X1

      UniProtKB/TrEMBL
      A6HTL1
      Conserved Domains (4) summary
      TIGR00864
      Location:92 → 167
      PCC; polycystin cation channel protein
      sd00031
      Location:63 → 86
      LRR_1; leucine-rich repeat [structural motif]
      pfam03736
      Location:171 → 210
      EPTP; EPTP domain
      pfam13855
      Location:61 → 121
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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