Stat4 signal transducer and activator of transcription 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stat4provided by RGD
Official Full Name: signal transducer and activator of transcription 4provided by RGD
Primary source: RGD:1305747
See related: EnsemblRapid:ENSRNOG00000014079 AllianceGenome:RGD:1305747
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables sequence-specific DNA binding activity. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Predicted to be located in cytoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Used to study obesity. Biomarker of asthma; chronic obstructive pulmonary disease; and metabolic dysfunction and alcohol associated liver disease. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; autoimmune disease (multiple); breast cancer (multiple); carcinoma (multiple); and scleroderma (multiple). Orthologous to several human genes including STAT1 (signal transducer and activator of transcription 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Testes (RPKM 651.5), Spleen (RPKM 103.9) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q22

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (56964617..57080523, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (49472660..49588540, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (54340649..54457753, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of STAT4 on myocardial ischemia-reperfusion injury and the underlying mechanisms.
Title: Effects of STAT4 on myocardial ischemia‑reperfusion injury and the underlying mechanisms.
STAT4 regulates cardiomyocyte apoptosis in rat models of diabetic cardiomyopathy.
Title: STAT4 regulates cardiomyocyte apoptosis in rat models of diabetic cardiomyopathy.
silencing of STAT4 could hinder the progression of autoimmune myocarditis by balancing the expression of Th1/Th2 inflammatory cytokines via the NF-kappaB pathway.
Title: Silencing of STAT4 Protects Against Autoimmune Myocarditis by Regulating Th1/Th2 Immune Response via Inactivation of the NF-κB Pathway in Rats.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T-helper 1 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cellular response to cytokine stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic stem cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in interleukin-12-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within leukocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in response to interleukin-6	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: signal transducer and activator of transcription 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012226.1 → NP_001012226.1 signal transducer and activator of transcription 4

Status: PROVISIONAL

Source sequence(s)

BC081938

UniProtKB/TrEMBL

F7FAC1, Q66HB2

Related

ENSRNOP00000020032.7, ENSRNOT00000020032.8

Conserved Domains (4) summary

cd10375
Location:553 → 700

SH2_STAT4; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 4proteins

smart00964
Location:2 → 121

STAT_int; STAT protein, protein interaction domain

pfam01017
Location:140 → 314

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:316 → 562

STAT_bind; STAT protein, DNA binding domain