Ears2 glutamyl-tRNA synthetase 2, mitochondrial [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ears2provided by RGD
Official Full Name: glutamyl-tRNA synthetase 2, mitochondrialprovided by RGD
Primary source: RGD:1307904
See related: AllianceGenome:RGD:1307904
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307904
Summary: Predicted to enable glutamate-tRNA ligase activity and glutamate-tRNA(Gln) ligase activity. Predicted to be involved in glutamyl-tRNA aminoacylation and tRNA aminoacylation for mitochondrial protein translation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 12. Orthologous to human EARS2 (glutamyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 67.2), Liver (RPKM 58.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (186025740..186057165, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (176597986..176625848, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (191997512..192025350, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables glutamate-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate-tRNA ligase activity	ISO Inferred from Sequence Orthology more info
enables glutamate-tRNA(Gln) ligase activity	ISO Inferred from Sequence Orthology more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glutamyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamyl-tRNA aminoacylation	ISO Inferred from Sequence Orthology more info
involved_in tRNA aminoacylation for mitochondrial protein translation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial

Names: glutamyl-tRNA synthetase 2 mitochondrial (putative); probable glutamate--tRNA ligase, mitochondrial; probable glutamyl-tRNA synthetase, mitochondrial

NP_001152965.1

EC 6.1.1.17

XP_038938800.1

EC 6.1.1.17

XP_063123692.1

EC 6.1.1.17

XP_063123699.1

EC 6.1.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159493.1 → NP_001152965.1 nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6I8V7, M0RAI4

Conserved Domains (2) summary

cd00808
Location:36 → 361

GluRS_core; catalytic core domain of discriminating glutamyl-tRNA synthetase

PRK01406
Location:36 → 521

gltX; glutamyl-tRNA synthetase; Reviewed

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

186025740..186057165 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063267629.1 → XP_063123699.1 nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial isoform X2
XM_039082872.2 → XP_038938800.1 nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial isoform X1

Conserved Domains (1) summary

PRK01406
Location:36 → 351

gltX; glutamyl-tRNA synthetase; Reviewed
XM_063267622.1 → XP_063123692.1 nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial isoform X1