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    Jph3 junctophilin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307916, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Jph3provided by RGD
    Official Full Name
    junctophilin 3provided by RGD
    Primary source
    RGD:1308416
    See related
    EnsemblRapid:ENSRNOG00000018784 AllianceGenome:RGD:1308416
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including exploration behavior; memory; and regulation of ryanodine-sensitive calcium-release channel activity. Predicted to act upstream of or within several processes, including learning; neuromuscular process controlling balance; and regulation of neuronal synaptic plasticity. Predicted to be located in endoplasmic reticulum. Predicted to be part of junctional membrane complex. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. Human ortholog(s) of this gene implicated in Huntington's disease-like 2. Orthologous to human JPH3 (junctophilin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 273.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Jph3 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (66702497..66763948)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (49793967..49855338)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (54553419..54613477)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483656 Neighboring gene uncharacterized LOC102550418 Neighboring gene small nucleolar RNA SNORA72 Neighboring gene kelch domain containing 4 Neighboring gene microRNA 3564 Neighboring gene solute carrier family 7 member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Motor discoordination in mutant mice lacking junctophilin type 3. Nishi M, et al. Biochem Biophys Res Commun, 2002 Mar 29. PMID 11906164
    2. Homer1a is a core brain molecular correlate of sleep loss. Maret S, et al. Proc Natl Acad Sci U S A, 2007 Dec 11. PMID 18077435, Free PMC Article
    3. Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins. Moriguchi S, et al. Proc Natl Acad Sci U S A, 2006 Jul 11. PMID 16809425, Free PMC Article
    4. Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity. Kakizawa S, et al. EMBO J, 2007 Apr 4. PMID 17347645, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in exploration behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within locomotion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuromuscular process controlling balance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ryanodine-sensitive calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of junctional membrane complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of junctional membrane complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    junctophilin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107437.1 → NP_001100907.1  junctophilin-3

      See identical proteins and their annotated locations for NP_001100907.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A6IZQ1, D3ZWH2
      Related
      ENSRNOP00000025392.4, ENSRNOT00000025392.7
      Conserved Domains (1) summary
      pfam02493
      Location:311 → 333
      MORN; MORN repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      66702497..66763948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097780.2 → XP_038953708.1  junctophilin-3 isoform X1

      Conserved Domains (1) summary
      PLN03185
      Location:5 → 144
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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