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    Tanc2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303599, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tanc2provided by RGD
    Official Full Name
    tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2provided by RGD
    Primary source
    RGD:1309285
    See related
    EnsemblRapid:ENSRNOG00000052840 AllianceGenome:RGD:1309285
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309285
    Summary
    A structural constituent of postsynaptic density. Involved in dense core granule cytoskeletal transport; regulation of dendritic spine development; and regulation of dendritic spine morphogenesis. Located in dendritic spine. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in intellectual developmental disorder with autistic features and language delay, with or without seizures. Orthologous to human TANC2 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 130.9), Kidney (RPKM 121.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tanc2 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (91052860..91373291)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (90553124..90873477)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (93811350..94132418)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480889 Neighboring gene transfer RNA valine (anticodon AAC) 25 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC120095191 Neighboring gene U6 spliceosomal RNA Neighboring gene snurportin 1, pseudogene 1 Neighboring gene uncharacterized LOC120095193 Neighboring gene cytochrome b-561 Neighboring gene angiotensin I converting enzyme

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins. Han S, et al. J Neurosci, 2010 Nov 10. PMID 21068316, Free PMC Article
    2. Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca(2+)/CaM Controls DCV Binding and Liprin-α/TANC2 Recruits DCVs to Postsynaptic Sites. Stucchi R, et al. Cell Rep, 2018 Jul 17. PMID 30021165, Free PMC Article
    3. Seizures are regulated by ubiquitin-specific peptidase 9 X-linked (USP9X), a de-ubiquitinase. Paemka L, et al. PLoS Genet, 2015 Mar. PMID 25763846, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. liprin-alpha and TANC2 are not part of the KIF1A-cargo complex but capture dense core vesicles at dendritic spines.
      Title: Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca(2+)/CaM Controls DCV Binding and Liprin-α/TANC2 Recruits DCVs to Postsynaptic Sites.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of postsynaptic density EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables structural constituent of postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of postsynaptic density IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dense core granule cytoskeletal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of postsynaptic density structure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dendritic spine morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in postsynaptic density, intracellular component IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density, intracellular component IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein TANC2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191653.1 → NP_001178582.1  protein TANC2

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      F1LTE0
      UniProtKB/TrEMBL
      A6HJY7
      Related
      ENSRNOP00000075014.3, ENSRNOT00000081937.3
      Conserved Domains (7) summary
      PHA03095
      Location:856 → 1150
      PHA03095; ankyrin-like protein; Provisional
      PHA03378
      Location:1493 → 1637
      PHA03378; EBNA-3B; Provisional
      COG0457
      Location:1240 → 1357
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1096 → 1222
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1247 → 1272
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1100 → 1130
      ANK; ANK repeat [structural motif]
      pfam13191
      Location:341 → 427
      AAA_16; AAA ATPase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      91052860..91373291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086155.2 → XP_038942083.1  protein TANC2 isoform X7

      UniProtKB/TrEMBL
      A0A0G2K9J0
      Conserved Domains (6) summary
      PHA03095
      Location:859 → 1153
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:1442 → 1637
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:1253 → 1371
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1099 → 1225
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1260 → 1285
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1103 → 1133
      ANK; ANK repeat [structural motif]

    2. XM_039086153.2 → XP_038942081.1  protein TANC2 isoform X7

      UniProtKB/TrEMBL
      A0A0G2K9J0
      Conserved Domains (6) summary
      PHA03095
      Location:859 → 1153
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:1442 → 1637
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:1253 → 1371
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1099 → 1225
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1260 → 1285
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1103 → 1133
      ANK; ANK repeat [structural motif]

    3. XM_039086147.2 → XP_038942075.1  protein TANC2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K9J0
      Conserved Domains (6) summary
      PHA03095
      Location:930 → 1224
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:1513 → 1708
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:1324 → 1442
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1170 → 1296
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1331 → 1356
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1174 → 1204
      ANK; ANK repeat [structural motif]

    4. XM_008768351.4 → XP_008766573.1  protein TANC2 isoform X2

      See identical proteins and their annotated locations for XP_008766573.1

      UniProtKB/TrEMBL
      A0A0G2K9J0, A0A8L2R2A4
      Related
      ENSRNOP00000069281.2, ENSRNOT00000077280.3
      Conserved Domains (10) summary
      cd00204
      Location:1168 → 1293
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:1331 → 1356
      TPR; TPR repeat [structural motif]
      pfam03153
      Location:1490 → 1715
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12796
      Location:1178 → 1270
      Ank_2; Ankyrin repeats (3 copies)
      pfam13191
      Location:415 → 501
      AAA_16; AAA ATPase domain
      pfam13414
      Location:1377 → 1440
      TPR_11; TPR repeat
      pfam13428
      Location:1410 → 1452
      TPR_14; Tetratricopeptide repeat
      pfam13637
      Location:962 → 1011
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:1174 → 1204
      ANK; ANK repeat [structural motif]
      cl14876
      Location:469 → 613
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    5. XM_039086149.2 → XP_038942077.1  protein TANC2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K9J0
      Conserved Domains (6) summary
      PHA03095
      Location:930 → 1224
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:1503 → 1698
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:1314 → 1432
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1170 → 1296
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1321 → 1346
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1174 → 1204
      ANK; ANK repeat [structural motif]

    6. XM_008768353.4 → XP_008766575.1  protein TANC2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K9J0
      Related
      ENSRNOP00000111586.1, ENSRNOT00000146875.1
      Conserved Domains (10) summary
      cd00204
      Location:1168 → 1293
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:1321 → 1346
      TPR; TPR repeat [structural motif]
      pfam03153
      Location:1480 → 1705
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12796
      Location:1178 → 1270
      Ank_2; Ankyrin repeats (3 copies)
      pfam13191
      Location:415 → 501
      AAA_16; AAA ATPase domain
      pfam13414
      Location:1367 → 1430
      TPR_11; TPR repeat
      pfam13428
      Location:1400 → 1442
      TPR_14; Tetratricopeptide repeat
      pfam13637
      Location:962 → 1011
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:1174 → 1204
      ANK; ANK repeat [structural motif]
      cl14876
      Location:469 → 613
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    7. XM_039086150.2 → XP_038942078.1  protein TANC2 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K9J0
      Conserved Domains (7) summary
      PHA03095
      Location:893 → 1187
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:1476 → 1671
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:1287 → 1405
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1133 → 1259
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1294 → 1319
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1137 → 1167
      ANK; ANK repeat [structural motif]
      pfam13191
      Location:378 → 464
      AAA_16; AAA ATPase domain

    8. XM_039086151.2 → XP_038942079.1  protein TANC2 isoform X6

      UniProtKB/TrEMBL
      A6HJY7
      Conserved Domains (7) summary
      PHA03095
      Location:893 → 1187
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:1476 → 1671
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:1287 → 1405
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1133 → 1259
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1294 → 1319
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1137 → 1167
      ANK; ANK repeat [structural motif]
      pfam13191
      Location:378 → 464
      AAA_16; AAA ATPase domain

    9. XM_039086157.2 → XP_038942085.1  protein TANC2 isoform X8

      UniProtKB/TrEMBL
      A6HJY7
      Conserved Domains (7) summary
      PHA03095
      Location:856 → 1150
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:1439 → 1634
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:1250 → 1368
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1096 → 1222
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1257 → 1282
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1100 → 1130
      ANK; ANK repeat [structural motif]
      pfam13191
      Location:341 → 427
      AAA_16; AAA ATPase domain

    10. XM_063269198.1 → XP_063125268.1  protein TANC2 isoform X9

      UniProtKB/TrEMBL
      A6HJY7

    11. XM_039086154.2 → XP_038942082.1  protein TANC2 isoform X7

      UniProtKB/TrEMBL
      A0A0G2K9J0
      Conserved Domains (6) summary
      PHA03095
      Location:859 → 1153
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:1442 → 1637
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:1253 → 1371
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1099 → 1225
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1260 → 1285
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1103 → 1133
      ANK; ANK repeat [structural motif]

    12. XM_039086152.1 → XP_038942080.1  protein TANC2 isoform X7

      UniProtKB/TrEMBL
      A0A0G2K9J0
      Conserved Domains (6) summary
      PHA03095
      Location:859 → 1153
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:1442 → 1637
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:1253 → 1371
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1099 → 1225
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1260 → 1285
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1103 → 1133
      ANK; ANK repeat [structural motif]

    13. XM_039086159.2 → XP_038942087.1  protein TANC2 isoform X10

      UniProtKB/TrEMBL
      A6HJY7
      Conserved Domains (7) summary
      PHA03095
      Location:766 → 1060
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:1349 → 1544
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:1160 → 1278
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1006 → 1132
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1167 → 1192
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1010 → 1040
      ANK; ANK repeat [structural motif]
      pfam13191
      Location:251 → 337
      AAA_16; AAA ATPase domain

    14. XM_039086156.2 → XP_038942084.1  protein TANC2 isoform X7

      UniProtKB/TrEMBL
      A0A0G2K9J0
      Conserved Domains (6) summary
      PHA03095
      Location:859 → 1153
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:1442 → 1637
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:1253 → 1371
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1099 → 1225
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1260 → 1285
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1103 → 1133
      ANK; ANK repeat [structural motif]

    15. XM_039086158.2 → XP_038942086.1  protein TANC2 isoform X10

      UniProtKB/TrEMBL
      A6HJY7
      Conserved Domains (7) summary
      PHA03095
      Location:766 → 1060
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:1349 → 1544
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:1160 → 1278
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1006 → 1132
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1167 → 1192
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1010 → 1040
      ANK; ANK repeat [structural motif]
      pfam13191
      Location:251 → 337
      AAA_16; AAA ATPase domain

    16. XM_039086160.2 → XP_038942088.1  protein TANC2 isoform X10

      UniProtKB/TrEMBL
      A6HJY7
      Conserved Domains (7) summary
      PHA03095
      Location:766 → 1060
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:1349 → 1544
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:1160 → 1278
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1006 → 1132
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1167 → 1192
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1010 → 1040
      ANK; ANK repeat [structural motif]
      pfam13191
      Location:251 → 337
      AAA_16; AAA ATPase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1LTE0.2 GenPept UniProtKB/Swiss-Prot:F1LTE0

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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