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    Tbc1d31 TBC1 domain family, member 31 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299949, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tbc1d31provided by RGD
    Official Full Name
    TBC1 domain family, member 31provided by RGD
    Primary source
    RGD:1587370
    See related
    EnsemblRapid:ENSRNOG00000006103 AllianceGenome:RGD:1587370
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wdr67
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in cilium assembly. Predicted to be located in centriolar satellite. Predicted to be active in ciliary basal body. Orthologous to human TBC1D31 (TBC1 domain family member 31). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 57.0), Kidney (RPKM 56.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tbc1d31 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (91316905..91396434)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (89427354..89506894)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (97778260..97839668)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene zinc fingers and homeoboxes 2 Neighboring gene uncharacterized LOC102553568 Neighboring gene derlin 1 Neighboring gene uncharacterized LOC134479907 Neighboring gene ribosomal protein L37A, pseudogene 14 Neighboring gene ribosomal protein S27a, pseudogene 10 Neighboring gene transfer RNA methionine (anticodon CAU) 2 Neighboring gene family with sequence similarity 83, member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 31
    Names
    WD repeat domain 67
    WD repeat-containing protein 67

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134842.1 → NP_001128314.1  TBC1 domain family member 31

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2JVE4, D3ZTA2
      Related
      ENSRNOP00000059695.1, ENSRNOT00000064264.3
      Conserved Domains (6) summary
      COG2319
      Location:34 → 346
      WD40; WD40 repeat [General function prediction only]
      pfam15346
      Location:693 → 842
      ARGLU; Arginine and glutamate-rich 1
      sd00039
      Location:43 → 81
      7WD40; WD40 repeat [structural motif]
      cl02495
      Location:460 → 609
      RabGAP-TBC; Rab-GTPase-TBC domain
      cl02567
      Location:39 → 334
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl23750
      Location:713 → 834
      vATP-synt_E; ATP synthase (E/31 kDa) subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      91316905..91396434
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078789.2 → XP_038934717.1  TBC1 domain family member 31 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JVE4, A0A8I5ZW52
      Related
      ENSRNOP00000069453.3, ENSRNOT00000086792.3
      Conserved Domains (4) summary
      sd00039
      Location:35 → 73
      7WD40; WD40 repeat [structural motif]
      pfam17380
      Location:676 → 990
      DUF5401; Family of unknown function (DUF5401)
      cl02495
      Location:420 → 611
      RabGAP-TBC; Rab-GTPase-TBC domain
      cl29593
      Location:31 → 326
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_063263256.1 → XP_063119326.1  TBC1 domain family member 31 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JVE4, A0A8I6AR49
      Related
      ENSRNOP00000096681.1, ENSRNOT00000098991.2

    3. XM_063263257.1 → XP_063119327.1  TBC1 domain family member 31 isoform X3

      UniProtKB/TrEMBL
      A6HRI7

    4. XM_039078791.2 → XP_038934719.1  TBC1 domain family member 31 isoform X3

      UniProtKB/TrEMBL
      A6HRI7
      Conserved Domains (2) summary
      pfam17380
      Location:431 → 745
      DUF5401; Family of unknown function (DUF5401)
      cl02495
      Location:175 → 366
      RabGAP-TBC; Rab-GTPase-TBC domain

    5. XM_039078793.2 → XP_038934721.1  TBC1 domain family member 31 isoform X4

      Conserved Domains (2) summary
      pfam17380
      Location:314 → 628
      DUF5401; Family of unknown function (DUF5401)
      cl02495
      Location:58 → 249
      RabGAP-TBC; Rab-GTPase-TBC domain
    Nucleotide Protein Strain
    Heading Accession and Version

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