Urad ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Uradprovided by RGD
Official Full Name: ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylaseprovided by RGD
Primary source: RGD:1595191
See related: EnsemblRapid:ENSRNOG00000050360 AllianceGenome:RGD:1595191
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity. Predicted to be involved in several processes, including purine nucleobase catabolic process; purine nucleoside catabolic process; and purine nucleoside monophosphate catabolic process. Predicted to be active in peroxisome. Orthologous to human URAD (ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 596.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 12p11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (12745388..12755034)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (7709278..7718925)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (9446808..9456777)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity	ISO Inferred from Sequence Orthology more info
enables carboxy-lyase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in AMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in GMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in IMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in adenosine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in allantoin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in amide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in dAMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in dGMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in deoxyadenosine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in deoxyguanosine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in deoxyinosine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in guanine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in hypoxanthine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in inosine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in urate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in urate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in urate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in xanthine catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase

NP_001385810.1

EC 4.1.1.97

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398881.1 → NP_001385810.1 putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A6K1A5, M0RCU5

Related

ENSRNOP00000067429.3, ENSRNOT00000074791.4

Conserved Domains (1) summary

pfam09349
Location:7 → 162

OHCU_decarbox; OHCU decarboxylase