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    Cdadc1 cytidine and dCMP deaminase domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361052, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdadc1provided by RGD
    Official Full Name
    cytidine and dCMP deaminase domain containing 1provided by RGD
    Primary source
    RGD:1311845
    See related
    EnsemblRapid:ENSRNOG00000012209 AllianceGenome:RGD:1311845
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including cytidine deaminase activity; importin-alpha family protein binding activity; and protein homodimerization activity. Predicted to be involved in DNA cytosine deamination and cytidine deamination. Predicted to be located in cytoplasm and nucleus. Orthologous to human CDADC1 (cytidine and dCMP deaminase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 314.9), Heart (RPKM 203.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdadc1 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (37902789..37934853, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (33726590..33755611, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (39865094..39894122, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene SET domain bifurcated histone lysine methyltransferase 2 Neighboring gene calcium binding protein 39-like Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC120097001 Neighboring gene uncharacterized LOC134481975 Neighboring gene ribosomal protein S9, pseudogene 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural and biological function of NYD-SP15 as a new member of cytidine deaminases. Xu Y, et al. Gene, 2016 May 25. PMID 26945630
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytidine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dCMP deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables importin-alpha family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA cytosine deamination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytidine deamination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytidine deamination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytidine and dCMP deaminase domain-containing protein 1
    NP_001012156.1
    NP_001386504.1
    NP_001386505.1
    XP_006252188.1
    XP_008768982.1
    XP_038949430.1
    XP_063130483.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012156.2 → NP_001012156.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001012156.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6K685, F1MAC1, Q5XIE7
      Conserved Domains (1) summary
      cl00269
      Location:75 → 152
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

    2. NM_001399575.1 → NP_001386504.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6A0N0, A0A8I6A301, A6K681
      Related
      ENSRNOP00000085311.1, ENSRNOT00000104311.2

    3. NM_001399576.1 → NP_001386505.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A0G2KAJ9, A0A8I6AFB7, A6K683
      Related
      ENSRNOP00000060798.4, ENSRNOT00000068353.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      37902789..37934853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008770760.4 → XP_008768982.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A0N0, A0A8I6A8W1, A6K681
      Related
      ENSRNOP00000087904.1, ENSRNOT00000103380.2
      Conserved Domains (2) summary
      cd01286
      Location:295 → 430
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
      cl00269
      Location:58 → 127
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

    2. XM_006252126.5 → XP_006252188.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A6K682
      Conserved Domains (2) summary
      cd01286
      Location:224 → 359
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
      cl00269
      Location:13 → 56
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

    3. XM_039093502.2 → XP_038949430.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2KAJ9
      Related
      ENSRNOP00000090984.2, ENSRNOT00000115313.2
      Conserved Domains (2) summary
      cd01286
      Location:320 → 455
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
      cl00269
      Location:75 → 152
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

    4. XM_063274413.1 → XP_063130483.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2KAJ9
    Nucleotide Protein Strain
    Heading Accession and Version

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