Nlrp4a NLR family, pyrin domain containing 4A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nlrp4aprovided by RGD
Official Full Name: NLR family, pyrin domain containing 4Aprovided by RGD
Primary source: RGD:1561918
See related: EnsemblRapid:ENSRNOG00000042030 AllianceGenome:RGD:1561918
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561918
Summary: Predicted to enable ATP binding activity. Predicted to be involved in regulation of inflammatory response. Predicted to be part of canonical inflammasome complex. Predicted to be active in cytoplasm. Orthologous to human NLRP4 (NLR family pyrin domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 2.3) and Uterus (RPKM 0.3) See more
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Genomic context

Location:: 1q12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (75086422..75173426, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (66171037..66258045, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (69326303..69443753, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of canonical inflammasome complex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NACHT, LRR and PYD domains-containing protein 4A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106220.2 → NP_001099690.1 NACHT, LRR and PYD domains-containing protein 4A

See identical proteins and their annotated locations for NP_001099690.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6KS49, D3ZUH1

Related

ENSRNOP00000051298.3, ENSRNOT00000043739.5

Conserved Domains (5) summary

cd00116
Location:692 → 953

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd08320
Location:10 → 91

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:749 → 772

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:692 → 720

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:149 → 316

NACHT; NACHT domain