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    Dazap1 DAZ associated protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362836, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Dazap1provided by RGD
    Official Full Name
    DAZ associated protein 1provided by RGD
    Primary source
    RGD:1305280
    See related
    EnsemblRapid:ENSRNOG00000031387 AllianceGenome:RGD:1305280
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA stem-loop binding activity; poly(G) binding activity; and poly(U) RNA binding activity. Predicted to act upstream of or within several processes, including fibroblast proliferation; maternal placenta development; and positive regulation of mRNA splicing, via spliceosome. Predicted to be located in cytosol; male germ cell nucleus; and nucleoplasm. Predicted to be part of ribonucleoprotein complex. Orthologous to human DAZAP1 (DAZ associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 133.0), Testes (RPKM 110.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dazap1 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10074342..10098810, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9423673..9448116, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12289895..12315897, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 19 open reading frame 25 Neighboring gene APC regulator of WNT signaling pathway 2 Neighboring gene ribosomal protein S15 Neighboring gene guanidinoacetate N-methyltransferase Neighboring gene NADH:ubiquinone oxidoreductase core subunit S7 Neighboring gene transfer RNA asparagine (anticodon GUU) 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DAZAP1, an hnRNP protein, is required for normal growth and spermatogenesis in mice. Hsu LC, et al. RNA, 2008 Sep. PMID 18669443, Free PMC Article
    2. Expression patterns of the DAZ-associated protein DAZAP1 in rat and human ovaries. Pan HA, et al. Fertil Steril, 2005 Oct. PMID 16209998
    3. Dynamic changes in intranuclear and subcellular localizations of mouse Prrp/DAZAP1 during spermatogenesis: the necessity of the C-terminal proline-rich region for nuclear import and localization. Kurihara Y, et al. Arch Histol Cytol, 2004 Nov. PMID 15700540
    4. The RNA ligands for mouse proline-rich RNA-binding protein (mouse Prrp) contain two consensus sequences in separate loop structure. Hori T, et al. Nucleic Acids Res, 2005. PMID 15647502, Free PMC Article
    5. Deleted in azoospermia associated protein 1 shuttles between nucleus and cytoplasm during normal germ cell maturation. Vera Y, et al. J Androl, 2002 Sep-Oct. PMID 12185095

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114376

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA stem-loop binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(G) binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within maternal placenta development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DAZ-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025742.1 → NP_001020913.1  DAZ-associated protein 1

      See identical proteins and their annotated locations for NP_001020913.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098930
      UniProtKB/TrEMBL
      A0A8I6A8F6, F2Z3S1, Q4KLZ3
      Related
      ENSRNOP00000090669.2, ENSRNOT00000100123.2
      Conserved Domains (2) summary
      cd12327
      Location:110 → 189
      RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:11 → 92
      RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10074342..10098810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240970.5 → XP_006241032.1  DAZ-associated protein 1 isoform X3

      See identical proteins and their annotated locations for XP_006241032.1

      UniProtKB/TrEMBL
      A0A8I6A8F6, A6K8N1
      Conserved Domains (2) summary
      cd12327
      Location:102 → 181
      RRM2_DAZAP1; RNA recognition motif 2 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:3 → 84
      RRM1_DAZAP1; RNA recognition motif 1 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

    2. XM_006240969.5 → XP_006241031.1  DAZ-associated protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006241031.1

      UniProtKB/TrEMBL
      A0A8I6A8F6, A0A8I6ANV1
      Conserved Domains (2) summary
      cd12327
      Location:103 → 182
      RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:3 → 84
      RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

    3. XM_039079402.2 → XP_038935330.1  DAZ-associated protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A8F6
      Conserved Domains (2) summary
      cd12327
      Location:111 → 190
      RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:11 → 92
      RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

    4. XM_063263744.1 → XP_063119814.1  DAZ-associated protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A8F6

    5. XM_006240968.5 → XP_006241030.1  DAZ-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006241030.1

      UniProtKB/TrEMBL
      A0A8I6A8F6, A0A8J8XF56
      Related
      ENSRNOP00000046032.5, ENSRNOT00000046886.6
      Conserved Domains (2) summary
      cd12327
      Location:111 → 190
      RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:11 → 92
      RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

    6. XM_063263745.1 → XP_063119815.1  DAZ-associated protein 1 isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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