Kcnn2 potassium calcium-activated channel subfamily N member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Kcnn2provided by RGD
Full Name: potassium calcium-activated channel subfamily N member 2provided by RGD
Primary source: RGD:2963
See related: EnsemblRapid:ENSRNOG00000016675 AllianceGenome:RGD:2963
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SK2; SKCa2; KCa2.2; SKCa 2
Summary: Enables calmodulin binding activity and small conductance calcium-activated potassium channel activity. Involved in positive regulation of potassium ion transport; potassium ion transport; and regulation of neuronal synaptic plasticity. Located in dendritic spine; membrane; and neuronal cell body. Used to study essential tremor. Human ortholog(s) of this gene implicated in myoclonic dystonia 34. Orthologous to human KCNN2 (potassium calcium-activated channel subfamily N member 2). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Note: The locus_ids 54262 and 103690147 are annotated independently on Rnor_6.0 (AR 105). [28 May 2015]
Expression: Biased expression in Adrenal (RPKM 70.4), Brain (RPKM 42.4) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (40004693..40445043)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (37817966..38258347)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (39331894..39479574)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KCa 2.2 (KCNN2): A physiologically and therapeutically important potassium channel.
Title: K(Ca) 2.2 (KCNN2): A physiologically and therapeutically important potassium channel.
Loss-of-function KCa2.2 mutations abolish channel activity.
Title: Loss-of-function K(Ca)2.2 mutations abolish channel activity.
Ventricular SK2 upregulation following angiotensin II challenge: Modulation by p21-activated kinase-1.
Title: Ventricular SK2 upregulation following angiotensin II challenge: Modulation by p21-activated kinase-1.
rSK1 appears to act as chaperone for rSK2 channels and expression of rSK1 may control the level of functional SK current in rat neurons.
Title: rSK1 in Rat Neurons: A Controller of Membrane rSK2?
Study characterized and genetically analyzed F344-Trdk/+ rats. Tremor behaviors were suppressed by anti-tremor agents for essential tremor, but not for Parkinson's disease. A missense mutation, I289N, was detected in the Kcnn2 gene of F344-Trdk/+ rats. Electrophysiological studies in HEK293 cells revealed that this mutation diminished KCNN2 channel function.
Title: Tremor dominant Kyoto (Trdk) rats carry a missense mutation in the gene encoding the SK2 subunit of small-conductance Ca(2+)-activated K(+) channel.
SK2 channels regulate mitochondrial respiration and mitochondrial Ca(2+) uptake.
Title: SK2 channels regulate mitochondrial respiration and mitochondrial Ca(2+) uptake.
EDH-mediated responses are impaired in superior mesenteric arteries of SHRSP because of a reduction in both TRPV4 and SKCa input to EDH.
Title: Downregulation of Endothelial Transient Receptor Potential Vanilloid Type 4 Channel and Small-Conductance of Ca2+-Activated K+ Channels Underpins Impaired Endothelium-Dependent Hyperpolarization in Hypertension.
Apamin-Sensitive K+ Current Upregulation in Volume-Overload Heart Failure is Associated with the Decreased Interaction of CK2 with SK2.
Title: Apamin-Sensitive K+ Current Upregulation in Volume-Overload Heart Failure is Associated with the Decreased Interaction of CK2 with SK2.
This study demonistrated that SK1 and SK2 transcripts showed strong expression starting from E15 in the striatum and decreased throughout pre- and postnatal development.
Title: Developmental mapping of small-conductance calcium-activated potassium channel expression in the rat nervous system.
Sarcoplasmic reticulum Ca(2+) release is both necessary and sufficient for the activation of SK channels in rat ventricular myocytes.
Title: Sarcoplasmic reticulum Ca²⁺ release is both necessary and sufficient for SK channel activation in ventricular myocytes.

Submit: New GeneRIF Correction See all GeneRIFs (17)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-actinin binding	ISO Inferred from Sequence Orthology more info
enables calcium-activated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables small conductance calcium-activated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables small conductance calcium-activated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables small conductance calcium-activated potassium channel activity	IEA Inferred from Electronic Annotation more info
enables small conductance calcium-activated potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables small conductance calcium-activated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in membrane repolarization during atrial cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transport	TAS Traceable Author Statement more info	PubMed
involved_in regulation of neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in smooth endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: small conductance calcium-activated potassium channel protein 2

Names: potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; small conductance calcium-activated potassium channel protein 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001309404.1 → NP_001296333.1 small conductance calcium-activated potassium channel protein 2 isoform 1

See identical proteins and their annotated locations for NP_001296333.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

H6VQ94

Conserved Domains (3) summary

smart01053
Location:413 → 491

CaMBD; Calmodulin binding domain

pfam03530
Location:125 → 232

SK_channel; Calcium-activated SK potassium channel

pfam07885
Location:320 → 399

Ion_trans_2; Ion channel
NM_019314.2 → NP_062187.1 small conductance calcium-activated potassium channel protein 2 isoform 2

See identical proteins and their annotated locations for NP_062187.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

P70604

UniProtKB/TrEMBL

A6IWU8

Conserved Domains (3) summary

smart01053
Location:413 → 488

CaMBD; Calmodulin binding domain

pfam03530
Location:125 → 232

SK_channel; Calcium-activated SK potassium channel

pfam07885
Location:320 → 399

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

40004693..40445043

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063277521.1 → XP_063133591.1 small conductance calcium-activated potassium channel protein 2 isoform X3

UniProtKB/TrEMBL

A0A0G2JUD7
XM_063277519.1 → XP_063133589.1 small conductance calcium-activated potassium channel protein 2 isoform X1

UniProtKB/TrEMBL

A0A0G2JUD7, A0A8L2QBG6

Related

ENSRNOP00000022530.5, ENSRNOT00000022530.6
XM_063277520.1 → XP_063133590.1 small conductance calcium-activated potassium channel protein 2 isoform X2

UniProtKB/TrEMBL

A0A0G2JUD7

Related

ENSRNOP00000069058.2, ENSRNOT00000083642.3