Ctu1 cytosolic thiouridylase subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ctu1provided by RGD
Official Full Name: cytosolic thiouridylase subunit 1provided by RGD
Primary source: RGD:1308740
See related: EnsemblRapid:ENSRNOG00000018334 AllianceGenome:RGD:1308740
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Atpbd3; RGD1308740
Summary: Predicted to enable tRNA binding activity. Predicted to be involved in tRNA wobble position uridine thiolation. Predicted to be located in cytosol. Predicted to be part of cytosolic tRNA wobble base thiouridylase complex. Orthologous to human CTU1 (cytosolic thiouridylase subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 25.4), Spleen (RPKM 24.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (103251983..103257778)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (94115431..94121224)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (99599608..99605412)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein urmylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA thio-modification	ISS Inferred from Sequence or Structural Similarity more info
involved_in tRNA wobble position uridine thiolation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA wobble uridine modification	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
part_of cytosolic tRNA wobble base thiouridylase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytoplasmic tRNA 2-thiolation protein 1

Names: ATP binding domain 3; ATP-binding domain-containing protein 3; cytoplasmic tRNA adenylyltransferase 1; cytosolic thiouridylase subunit 1 homolog

NP_001099721.1

EC 2.7.7.-

XP_006229046.1

EC 2.7.7.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106251.1 → NP_001099721.1 cytoplasmic tRNA 2-thiolation protein 1

See identical proteins and their annotated locations for NP_001099721.1

Status: PROVISIONAL

Source sequence(s)

CH473979

UniProtKB/Swiss-Prot

B1WBV0

Conserved Domains (3) summary

TIGR00269
Location:207 → 308

TIGR00269; TIGR00269 family protein

COG0037
Location:29 → 329

TilS; tRNA(Ile)-lysidine synthase TilS/MesJ [Translation, ribosomal structure and biogenesis]

cd01993
Location:54 → 243

Alpha_ANH_like_II; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

103251983..103257778

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006228984.5 → XP_006229046.1 cytoplasmic tRNA 2-thiolation protein 1 isoform X1

See identical proteins and their annotated locations for XP_006229046.1

UniProtKB/Swiss-Prot

B1WBV0

Related

ENSRNOP00000024690.4, ENSRNOT00000024690.6

Conserved Domains (3) summary

TIGR00269
Location:207 → 308

TIGR00269; TIGR00269 family protein

COG0037
Location:29 → 329

TilS; tRNA(Ile)-lysidine synthase TilS/MesJ [Translation, ribosomal structure and biogenesis]

cd01993
Location:54 → 243

Alpha_ANH_like_II; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...