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    Cdh26 cadherin 26 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311693, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdh26provided by RGD
    Official Full Name
    cadherin 26provided by RGD
    Primary source
    RGD:1311632
    See related
    EnsemblRapid:ENSRNOG00000053332 AllianceGenome:RGD:1311632
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including alpha-catenin binding activity; beta-catenin binding activity; and delta-catenin binding activity. Predicted to be involved in CD4-positive, alpha-beta T cell activation. Predicted to be located in microtubule cytoskeleton and plasma membrane. Orthologous to human CDH26 (cadherin 26). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 15.5), Spleen (RPKM 10.0) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdh26 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (185898185..185950892)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (165520523..165573191)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (173969004..174020867)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 3D Neighboring gene family with sequence similarity 217, member B Neighboring gene uncharacterized LOC102555003 Neighboring gene uncharacterized LOC120101828

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation. Caldwell JM, et al. Mucosal Immunol, 2017 Sep. PMID 28051089, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables delta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CD4-positive, alpha-beta T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adherens junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cadherin-like protein 26
    Names
    cadherin-like 26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191745.2 → NP_001178674.1  cadherin-like protein 26 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2K7Z8, A0A8I6AFI2
      Related
      ENSRNOP00000074411.1, ENSRNOT00000083970.3
      Conserved Domains (1) summary
      cd11304
      Location:144 → 246
      Cadherin_repeat; Cadherin tandem repeat domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      185898185..185950892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762509.4 → XP_008760731.1  cadherin-like protein 26 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRI2, A0A8I6AFI2
      Related
      ENSRNOP00000081002.1, ENSRNOT00000118182.2
      Conserved Domains (1) summary
      cd11304
      Location:144 → 246
      Cadherin_repeat; Cadherin tandem repeat domain

    2. XM_039105151.2 → XP_038961079.1  cadherin-like protein 26 isoform X4

      Conserved Domains (1) summary
      cd11304
      Location:144 → 246
      Cadherin_repeat; Cadherin tandem repeat domain

    3. XM_039105150.2 → XP_038961078.1  cadherin-like protein 26 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AFI2
      Conserved Domains (1) summary
      cd11304
      Location:144 → 246
      Cadherin_repeat; Cadherin tandem repeat domain

    4. XM_039105149.2 → XP_038961077.1  cadherin-like protein 26 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A4R4, A0A8I6AFI2
      Related
      ENSRNOP00000085846.1, ENSRNOT00000096904.2
      Conserved Domains (1) summary
      cd11304
      Location:144 → 246
      Cadherin_repeat; Cadherin tandem repeat domain
    Nucleotide Protein Strain
    Heading Accession and Version

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