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    Fign fidgetin, microtubule severing factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295649, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fignprovided by RGD
    Official Full Name
    fidgetin, microtubule severing factorprovided by RGD
    Primary source
    RGD:1308174
    See related
    EnsemblRapid:ENSRNOG00000004679 AllianceGenome:RGD:1308174
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP hydrolysis activity and microtubule severing ATPase activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to act upstream of or within locomotory behavior. Predicted to be located in nuclear matrix. Orthologous to human FIGN (fidgetin, microtubule severing factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 44.9), Kidney (RPKM 31.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fign in Genome Data Viewer
    Location:
    3q21
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (69045918..69169148, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (48637510..48760772, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (49992250..50120601, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350383 Neighboring gene uncharacterized LOC134486366 Neighboring gene uncharacterized LOC120101556 Neighboring gene glutamine amidotransferase class 1 domain containing 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Fidgetin impacts axonal growth and branching in a local mTOR signal dependent manner. Ma C, et al. Exp Neurol, 2023 Mar. PMID 36586551
    2. Interaction between fidgetin and protein kinase A-anchoring protein AKAP95 is critical for palatogenesis in the mouse. Yang Y, et al. J Biol Chem, 2006 Aug 4. PMID 16751186
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fidgetin impacts axonal growth and branching in a local mTOR signal dependent manner.
      Title: Fidgetin impacts axonal growth and branching in a local mTOR signal dependent manner.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule severing ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    fidgetin

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106484.1 → NP_001099954.1  fidgetin

      See identical proteins and their annotated locations for NP_001099954.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/TrEMBL
      A6HLW4, D3ZYS4
      Conserved Domains (3) summary
      smart00382
      Location:519 → 654
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:522 → 652
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:723 → 756
      Vps4_C; Vps4 C terminal oligomerization domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      69045918..69169148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761890.4 → XP_008760112.1  fidgetin isoform X2

      See identical proteins and their annotated locations for XP_008760112.1

      UniProtKB/TrEMBL
      A0A8I5ZRP0, A6HLW5
      Related
      ENSRNOP00000102928.1, ENSRNOT00000166797.1
      Conserved Domains (3) summary
      smart00382
      Location:508 → 643
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:511 → 641
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:712 → 745
      Vps4_C; Vps4 C terminal oligomerization domain

    2. XM_008761888.4 → XP_008760110.1  fidgetin isoform X1

      See identical proteins and their annotated locations for XP_008760110.1

      UniProtKB/TrEMBL
      A6HLW4, D3ZYS4
      Conserved Domains (3) summary
      smart00382
      Location:519 → 654
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:522 → 652
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:723 → 756
      Vps4_C; Vps4 C terminal oligomerization domain

    3. XM_063283273.1 → XP_063139343.1  fidgetin isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZRP0, A6HLW5
      Related
      ENSRNOP00000099831.1, ENSRNOT00000129006.1

    4. XM_008761889.4 → XP_008760111.1  fidgetin isoform X2

      See identical proteins and their annotated locations for XP_008760111.1

      UniProtKB/TrEMBL
      A0A8I5ZRP0, A6HLW5
      Conserved Domains (3) summary
      smart00382
      Location:508 → 643
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:511 → 641
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:712 → 745
      Vps4_C; Vps4 C terminal oligomerization domain
    Nucleotide Protein Strain
    Heading Accession and Version

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